Departamento de Neurobiología Celular Y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, 76215, Juriquilla, Querétaro, México.
Unit for Basic and Applied Microbiology, School of Natural Sciences, Autonomous University of Queretaro, Queretaro, Mexico.
J Mol Evol. 2022 Aug;90(3-4):271-282. doi: 10.1007/s00239-022-10057-1. Epub 2022 May 23.
MCTPs (Multiple C2 Domains and Transmembrane region Proteins) are evolutionarily and structurally related to other C2 proteins, which are central to exocytosis and membrane trafficking; however, their specific function has been little studied. MCTPs are associated with endosomes and the endoplasmic reticulum and possess three C2 domains (C2A-C2C) and two transmembrane regions (TMRs) well conserved in different species. Here, we generated structural models of the MCTP C2 domains of C. elegans and analyzed their putative function by docking, which revealed that these domains possess Ca- and lipid-binding pockets, suggesting that MCTPs play a significant, calcium-dependent role in membrane physiology.
MCTPs（多 C2 结构域和跨膜区蛋白）在进化和结构上与其他 C2 蛋白相关，C2 蛋白是胞吐作用和膜运输的核心；然而，它们的具体功能尚未得到充分研究。MCTPs 与内体和内质网相关联，具有三个 C2 结构域（C2A-C2C）和两个跨膜区（TMRs），在不同物种中高度保守。在这里，我们生成了线虫 MCTP C2 结构域的结构模型，并通过对接分析了它们的可能功能，结果表明这些结构域具有 Ca2+和脂质结合口袋，表明 MCTPs 在膜生理学中发挥着重要的、依赖 Ca2+的作用。
