Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, Boston, MA, USA.
Curr Top Behav Neurosci. 2022;58:515-535. doi: 10.1007/7854_2022_350.
Despite the prevalence of anhedonia across multiple psychiatric disorders, its relevance to treatment selection and prognostication can be unclear (Davey et al., Psychol Med 42(10):2071-81, 2012). Given the challenges in pharmacological and psychosocial treatment, there has been increasing attention devoted to neuroanatomically-targeted treatments. This chapter will present a brief introduction to circuit-targeted therapeutics in psychiatry (Sect. 1), an overview of brain mapping as it relates to anhedonia (Sect. 2), a review of existing studies on brain stimulation for anhedonia (Sect. 3), and a description of emerging approaches to circuit-based neuromodulation for anhedonia (Sect. 4).
尽管快感缺失存在于多种精神障碍中，但它与治疗选择和预后的关系可能并不明确（Davey 等人，《心理医学》42（10）：2071-81，2012）。鉴于在药物治疗和心理社会治疗方面存在挑战，人们越来越关注针对神经解剖结构的治疗方法。本章将简要介绍精神病学中的靶向回路治疗（第 1 节），概述与快感缺失相关的脑图谱（第 2 节），回顾现有的快感缺失脑刺激研究（第 3 节），并描述针对快感缺失的基于回路的神经调节的新兴方法（第 4 节）。
