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N -methyladenosine-RNA methylation promotes expression of solute carrier family 7 member 11, an uptake transporter of cystine for lipid reactive oxygen species scavenger glutathione synthesis, leading to hepatoblastoma ferroptosis resistance.

作者信息

Hill Ronald A, Liu Yong-Yu

机构信息

School of Basic Pharmaceutical and Toxicological Sciences, the University of Louisiana at Monroe, Monroe, Louisiana, USA.

出版信息

Clin Transl Med. 2022 May;12(5):e889. doi: 10.1002/ctm2.889.

DOI:10.1002/ctm2.889
PMID:35604883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9126359/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/9126359/7ca9d158319e/CTM2-12-e889-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/9126359/7ca9d158319e/CTM2-12-e889-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/9126359/7ca9d158319e/CTM2-12-e889-g001.jpg

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本文引用的文献

1
Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment.胱氨酸/谷氨酸逆向转运体在精神分裂症中的作用：从分子机制到新型生物标志物和治疗靶点。
Int J Mol Sci. 2021 Sep 8;22(18):9718. doi: 10.3390/ijms22189718.
2
xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling.xCT：将癌症代谢与氧化还原信号联系起来的关键分子。
Mol Ther. 2020 Nov 4;28(11):2358-2366. doi: 10.1016/j.ymthe.2020.08.021. Epub 2020 Sep 2.
3
Hepatoblastoma: current knowledge and promises from preclinical studies.肝母细胞瘤：当前认知与临床前研究的前景
系统X/谷胱甘肽/谷胱甘肽过氧化物酶4：耐药实体瘤治疗中细胞铁死亡的重要抗氧化系统。
Front Pharmacol. 2022 Aug 29;13:910292. doi: 10.3389/fphar.2022.910292. eCollection 2022.
Transl Gastroenterol Hepatol. 2020 Jul 5;5:42. doi: 10.21037/tgh.2019.12.03. eCollection 2020.
4
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion.铁死亡在癌症获得性耐药和免疫逃逸的十字路口。
Nat Rev Cancer. 2019 Jul;19(7):405-414. doi: 10.1038/s41568-019-0149-1.
5
Mechanisms of Anticancer Drug Resistance in Hepatoblastoma.肝母细胞瘤中抗癌药物耐药的机制
Cancers (Basel). 2019 Mar 22;11(3):407. doi: 10.3390/cancers11030407.
6
The Critical Role of RNA mA Methylation in Cancer.RNA mA 甲基化在癌症中的关键作用。
Cancer Res. 2019 Apr 1;79(7):1285-1292. doi: 10.1158/0008-5472.CAN-18-2965. Epub 2019 Mar 20.
7
An N-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.p53 前体 mRNA 中转录密码子 273 处的 N6-甲基腺苷促进 R273H 突变蛋白的表达和癌细胞的耐药性。
Biochem Pharmacol. 2019 Feb;160:134-145. doi: 10.1016/j.bcp.2018.12.014. Epub 2018 Dec 19.
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Ferroptosis: an iron-dependent form of nonapoptotic cell death.铁死亡：一种依赖于铁的非细胞凋亡性细胞死亡形式。
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Oncogene. 2008 Mar 6;27(11):1618-28. doi: 10.1038/sj.onc.1210796. Epub 2007 Sep 10.