Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States.
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States; Department of Materials Science and Engineering, The Pennsylvania State University, United States.
Appl Radiat Isot. 2022 Aug;186:110296. doi: 10.1016/j.apradiso.2022.110296. Epub 2022 May 18.
Copper-67 (Cu) has physical characteristics useful for both therapy and imaging. However, its applicability has been hindered by the complexity of obtaining large quantities of a product with high specific activity. With the advancement of Cu production methods, suitable radioisotope carriers are sought. Lanthanide phosphate nanoparticles have demonstrated their multifunctional characteristics for biomedical applications and, more recently, their potential in radiopharmaceuticals. Thus, we produced luminescent lanthanide phosphate nanoparticles with core and core-shell structures, incorporating Cu during their synthesis. The nanoparticles exhibited hexagonal crystalline structure and spherical morphology with sizes below 6 nm. The luminescent colloidal suspensions evidenced the characteristic D-F for Eu, providing the red color under UV light. A radiochemical yield of Cu >95% was obtained with both core and core-shell LaPO:Eu. The core-shell nanoparticles reduced the release of Cu by a factor of ∼2 over that from the core, which continuously decreased with time. Multifunctional LnPO nanoparticles have the potential to be used as a carrier of single or multiple radioisotopes to enhance image-guided targeted nano-radiopharmaceutical therapy.
铜-67（Cu）具有对治疗和成像都有用的物理特性。然而，由于获得高比活度大量产品的复杂性，其应用受到了限制。随着 Cu 生产方法的进步，人们正在寻找合适的放射性同位素载体。磷镧纳米粒子已证明其在生物医学应用中的多功能特性，最近还证明了其在放射性药物中的潜力。因此，我们在合成过程中掺入 Cu ，制备了具有核壳结构的发光镧磷纳米粒子。纳米粒子呈现出六方晶系结构和球形形态，尺寸小于 6nm。发光胶体悬浮液表现出 Eu 的特征 D-F，在紫外光下呈现红色。核和核壳 LaPO：Eu 的 Cu 放射化学产率均大于 95%。核壳纳米粒子将 Cu 的释放减少了约 2 倍，而核壳纳米粒子的释放随时间持续减少。多功能 LnPO 纳米粒子有可能被用作单一或多种放射性同位素的载体，以增强图像引导的靶向纳米放射性药物治疗。
