Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda-shi, 278-8510 Chiba, Japan.
National Institutes for Quantum Science and Technology, 1233 Watanuki, Takasaki-shi, 370-1292 Gunma, Japan.
J Pharm Sci. 2023 Jan;112(1):132-137. doi: 10.1016/j.xphs.2022.05.013. Epub 2022 May 20.
To develop and assess new dosage forms for the alternative to existing oral medication for peripheral neuropathy, a hydrogel film in the skin patch formation containing tramadol hydrochloride (TRA), a water-soluble drug used as an analgesic, was prepared and evaluated. A hydrogel film composed of 20%(w/w) hydroxypropyl methylcellulose (HPMC) irradiated with electron beams had high transparency and elasticity similar to commercially available wound dressings and soft tissues, suggesting that it is a suitable substrate for TRA. The inclusion of TRA was enabled by immersing the HPMC hydrogel film in TRA aqueous solution. The release and skin permeation of TRA from TRA-containing hydrogel films differed depending on the electron beam dose. Moreover, the analgesic effects in mice were confirmed in a dose-dependent manner. This study demonstrated the usefulness of a hydrogel film containing TRA as a new dosage form alternative to the existing oral medication for peripheral neuropathy.
为开发和评估用于替代现有外周神经病口服药物的新剂型，制备并评价了一种盐酸曲马多（TRA）水凝胶薄膜皮肤贴剂，TRA 是一种水溶性药物，用作镇痛药。由电子束辐照的 20%（w/w）羟丙基甲基纤维素（HPMC）组成的水凝胶薄膜具有类似于市售伤口敷料和软组织的高透明度和弹性，表明其是 TRA 的合适基质。通过将 HPMC 水凝胶薄膜浸入 TRA 水溶液中，可以实现 TRA 的包封。载 TRA 的水凝胶薄膜的释放和 TRA 的经皮渗透随电子束剂量而不同。此外，在小鼠中证实了 TRA 具有剂量依赖性的镇痛作用。这项研究表明，含有 TRA 的水凝胶薄膜作为替代现有外周神经病口服药物的新剂型是有用的。
