Amanzholkyzy Arailym, Zhumagaliyeva Shynar, Sultanova Nurgul, Abilov Zharylkasyn, Ongalbek Damira, Donbayeva Elvira, Niyazbekova Aktoty, Mukazhanova Zhazira
Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, Kazakhstan.
Department of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.
Molecules. 2025 Mar 18;30(6):1354. doi: 10.3390/molecules30061354.
Hydrogel delivery systems are popular dosage forms that have a number of advantages, such as ease of use, painlessness, increased efficiency due to prolongation of rheological, swelling and sorption characteristics, regulation of drug release, and stimulus sensitivity. Particular interest is shown in hydrogels of cellulose ether derivatives due to the possibility of obtaining their modified forms to vary the solubility, the degree of prolonged action, and the release of the active substance, as well as their widespread availability, affordability, and the possibility of sourcing raw materials from different sources. Hydroxypropyl methylcellulose (HPMC, "hypromellose") is one of the most popular cellulose ethers in the production of medicines as a filler, coating and carrier. Research on hydrogel carriers based on polymer complexes and modified forms of HPMC using acrylic, citric, and lactic acids, PVP, chitosan, Na-CMC, and gelatin is of particular interest, as they provide the necessary rheological and swelling characteristics. There is growing interest in medical transdermal hydrogels, films, capsules, membranes, nanocrystals, and nanofibers based on HPMC with the incorporation of biologically active substances (BASs), especially those of plant origin, as antibacterial, wound-healing, antimicrobial, mucoadhesive, anti-inflammatory, and antioxidant agents. The aim of this article is to review modern research and achievements in the field of hydrogel systems based on cellulose ethers, particularly HPMC, analyzing their properties, methods of production, and prospects for application in medicine and pharmacy.
水凝胶给药系统是一种流行的剂型，具有许多优点，如使用方便、无痛、由于流变学、溶胀和吸附特性的延长而提高效率、药物释放的调节以及刺激敏感性。由于可以获得其改性形式以改变溶解度、延长作用程度和活性物质的释放，以及它们广泛的可用性、可承受性和从不同来源获取原材料的可能性，纤维素醚衍生物水凝胶受到了特别关注。羟丙基甲基纤维素（HPMC，“羟丙甲纤维素”）是药物生产中最常用的纤维素醚之一，用作填充剂、包衣和载体。基于聚合物复合物和使用丙烯酸、柠檬酸和乳酸、聚乙烯吡咯烷酮、壳聚糖、羧甲基纤维素钠和明胶的HPMC改性形式的水凝胶载体的研究特别令人感兴趣，因为它们提供了必要的流变学和溶胀特性。基于HPMC并掺入生物活性物质（BASs），特别是植物来源的生物活性物质，作为抗菌、伤口愈合、抗微生物、粘膜粘附、抗炎和抗氧化剂的医用透皮水凝胶、薄膜、胶囊、膜、纳米晶体和纳米纤维越来越受到关注。本文的目的是综述基于纤维素醚，特别是HPMC的水凝胶系统领域的现代研究和成果，分析它们的性质、生产方法以及在医学和药学中的应用前景。
