铑(II)催化的芳基环丁烷 C(sp )-H 二胺化反应。
Rhodium(II)-Catalyzed C(sp )-H Diamination of Arylcyclobutanes.
机构信息
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202205493. doi: 10.1002/anie.202205493. Epub 2022 Jun 13.
PMID:35606340
Abstract
Activated by multiple consecutive oxidative radical-polar crossover and desaturation processes, the selective diamination of arylcyclobutanes, which is difficult to perform by classical metallonitrene C-H insertion, was achieved in a short time by rhodium(II) catalysis using N-fluorobenzenesulfonimide (NFSI) as the oxidant and nitrogen source.
摘要
通过多次连续的氧化自由基极性交叉和去饱和过程，芳基环丁烷的选择性二胺化反应得以实现，这是通过经典的金属亚氮化物 C-H 插入难以完成的。该反应在铑（II）催化下，使用 N-氟代苯磺酰胺（NFSI）作为氧化剂和氮源，在短时间内完成。
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