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生物强化番茄为维生素 D 充足提供了新途径。

Biofortified tomatoes provide a new route to vitamin D sufficiency.

机构信息

John Innes Centre, Norwich Research Park, Norwich, UK.

Institute of Sciences of Food Production, C.N.R., Unit of Lecce, Lecce, Italy.

出版信息

Nat Plants. 2022 Jun;8(6):611-616. doi: 10.1038/s41477-022-01154-6. Epub 2022 May 23.

DOI:10.1038/s41477-022-01154-6
PMID:35606499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9213236/
Abstract

Poor vitamin D status is a global health problem; insufficiency underpins higher risk of cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D and plants are very poor sources. We have engineered the accumulation of provitamin D in tomato by genome editing, modifying a duplicated section of phytosterol biosynthesis in Solanaceous plants, to provide a biofortified food with the added possibility of supplement production from waste material.

摘要

维生素 D 状况不佳是一个全球性的健康问题；不足会增加患癌症、神经认知能力下降和全因死亡率的风险。大多数食物含有的维生素 D 很少，而植物的含量非常低。我们通过基因组编辑工程在番茄中积累了前维生素 D，修饰了茄科植物中植物固醇生物合成的重复部分，提供了一种富含生物强化食品的可能性，并可利用废物生产补充剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d54/9213236/81be2e95bd49/41477_2022_1154_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d54/9213236/1702694b0718/41477_2022_1154_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d54/9213236/294b19e046e5/41477_2022_1154_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d54/9213236/81be2e95bd49/41477_2022_1154_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d54/9213236/1702694b0718/41477_2022_1154_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d54/9213236/294b19e046e5/41477_2022_1154_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d54/9213236/81be2e95bd49/41477_2022_1154_Fig3_ESM.jpg

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