Zhou Wenbo, Xue Pingping, Yang Yuqi, Xia Lin, Yu Bin
International Genome Center, Jiangsu University, Zhenjiang, P.R. China.
Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, P.R. China.
J Perinat Med. 2022 May 25;50(8):1115-1123. doi: 10.1515/jpm-2021-0665. Print 2022 Oct 26.
N6-methyladenosine (m6A) is one of the most common epigenetic modifications of eukaryotic RNA. Under the jointly reversible regulation of related enzymes, m6A regulates many aspects of RNA, such as translation, stability and degradation. The aim of this study is to investigate the role of m6A in placenta-related diseases.
Data were compiled from 2018 to 2021 citations in PubMed and Google Scholar using the keywords: placenta AND N6-methyladenosine. Seven studies were included.
In this study, we introduced some conventional methods to detect m6A modification at the whole RNA, region (peak) and single base levels. We also summarized the current studies of m6A modification in the placenta and briefly describe m6A in placental-related diseases, including recurrent miscarriage (RM), preeclampsia (PE) and gestational diabetes mellitus (GDM).
Although the relevant reports are still in the preliminary stage and some results are inconsistent, studies on methylation m6A modification have contributed new ideas for the research of reproductive diseases, providing a new basis for the diagnosis, treatment, prognosis and monitoring of related diseases.
N6-甲基腺苷（m6A）是真核生物RNA最常见的表观遗传修饰之一。在相关酶的共同可逆调控下，m6A调节RNA的许多方面，如翻译、稳定性和降解。本研究旨在探讨m6A在胎盘相关疾病中的作用。
使用关键词“胎盘”和“N6-甲基腺苷”，收集了2018年至2021年PubMed和谷歌学术搜索中的数据。共纳入7项研究。
在本研究中，我们介绍了一些在全RNA、区域（峰）和单碱基水平检测m6A修饰的传统方法。我们还总结了目前关于胎盘m6A修饰的研究，并简要描述了m6A在胎盘相关疾病中的情况，包括复发性流产（RM）、子痫前期（PE）和妊娠期糖尿病（GDM）。
尽管相关报道仍处于初步阶段且一些结果不一致，但对m6A甲基化修饰的研究为生殖疾病的研究贡献了新的思路，为相关疾病的诊断、治疗、预后及监测提供了新的依据。
