Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing, 210029, People's Republic of China.
Reprod Sci. 2023 Nov;30(11):3144-3152. doi: 10.1007/s43032-023-01250-8. Epub 2023 Jun 7.
Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification. In addition, epitranscriptional modification of m6A is closely related to the metabolic processes of placental tissues and cells in preeclampsia. This article reviews the composition, mode of action, and bioinformatics analysis of m6A modification-related proteins, and their biological function in the progression of preeclampsia. The relationship between m6A modification and preeclampsia risk factors, such as diabetes, cardiovascular disease, obesity, and psychological stress, is summarized to provide new ideas for studying PE-targeting molecules.
近年来，N6-甲基腺苷（m6A）的转录后修饰在子痫前期发病机制的研究中受到越来越多的关注。m6A 测序技术的进步揭示了 m6A 修饰的分子机制和重要性。此外，m6A 转录后修饰与子痫前期胎盘组织和细胞的代谢过程密切相关。本文综述了 m6A 修饰相关蛋白的组成、作用模式和生物信息学分析及其在子痫前期进展中的生物学功能。总结了 m6A 修饰与子痫前期危险因素（如糖尿病、心血管疾病、肥胖和心理压力）的关系，为研究 PE 靶向分子提供了新的思路。
