Maassen Stan J, van der Ham Anne M, Cornelissen Jeroen J L M
Laboratory for Biomolecular Nanotechnology, MESA+ Institute, University of Twente, P.O. Box 207, 7500 AE Enschede, The Netherlands.
ACS Macro Lett. 2016 Aug 16;5(8):987-994. doi: 10.1021/acsmacrolett.6b00509. Epub 2016 Aug 3.
Protein cages, such as viruses, are well-defined biological nanostructures which are highly symmetrical and monodisperse. They are found in various shapes and sizes and can encapsulate or template non-native materials. Furthermore, the proteins can be chemically or genetically modified giving them new properties. For these reasons, these protein structures have received increasing attention in the field of polymer-protein hybrid materials over the past years, however, advances are still to be made. This Viewpoint highlights the different ways polymers and protein cages or their subunits have been combined to understand self-assembly and create functional materials.
蛋白质笼，如病毒，是定义明确的生物纳米结构，具有高度的对称性和单分散性。它们有各种形状和大小，能够封装或作为非天然材料的模板。此外，蛋白质可以进行化学或基因修饰，赋予它们新的特性。由于这些原因，在过去几年中，这些蛋白质结构在聚合物-蛋白质杂化材料领域受到了越来越多的关注，然而，仍有待取得进展。本观点强调了聚合物与蛋白质笼或其亚基相结合的不同方式，以理解自组装并创造功能材料。
