The Affiliated Nanhua Hospital, Department of General Surgery, Hengyang Medical School, University of South China, Hengyang 421001, China.
The Affiliated Nanhua Hospital, Department of Anus and Bowels, Hengyang Medical School, University of South China, Hengyang 421001, China.
Acta Biochim Biophys Sin (Shanghai). 2022 Apr 25;54(4):452-462. doi: 10.3724/abbs.2022022.
The long non-coding RNA (lncRNA) forebrain embryonic zinc finger protein 1 antisense RNA1 (FEZF1-AS1) was recently identified as an oncogenic gene in several types of tumors. The biological function of FEZF1-AS1 in rectal cancer progression, however, remains unknown. In the present study, we discover that FEZF1-AS1 is significantly upregulated in rectal cancer tissues and cells. Knocking down of FEZF1-AS1 suppresses cell proliferation, migration, and invasion , and tumorigenesis . Furthermore, FEZF1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-632, resulting in the suppression of family with sequence similarity 83, member A (FAM83A). Overall, our findings reveal that FEZF1-AS1/miR-632/FAM83A axis plays an oncogenic role in rectal cancer progression, suggesting that it may be a novel therapeutic target for rectal cancer.
长链非编码 RNA (lncRNA) 脑前胚胎锌指蛋白 1 反义 RNA1 (FEZF1-AS1) 最近被鉴定为多种类型肿瘤的致癌基因。然而，FEZF1-AS1 在直肠癌进展中的生物学功能尚不清楚。在本研究中，我们发现 FEZF1-AS1 在直肠癌组织和细胞中显著上调。FEZF1-AS1 的敲低抑制细胞增殖、迁移和侵袭，以及肿瘤发生。此外，FEZF1-AS1 作为 miR-632 的竞争性内源 RNA (ceRNA)，导致家族与序列相似性 83，成员 A (FAM83A) 的抑制。总的来说，我们的研究结果表明 FEZF1-AS1/miR-632/FAM83A 轴在直肠癌进展中发挥致癌作用，提示其可能成为直肠癌的一种新的治疗靶点。
