基因型和口周肌肉组织对上颌骨和下颌骨发育的影响。
Influence of genotype and perioral musculature on maxillary and mandibular development.
作者信息
Hansen Sarah E, Petrone Joseph F A, Burnheimer John M, Vieira Alexandre R
机构信息
Resident, Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Assistant Professor, Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Angle Orthod. 2022 Sep 1;92(5):628-634. doi: 10.2319/112821-868.1. Epub 2022 May 24.
OBJECTIVES
To determine whether there is an association between skeletal jaw position and perioral musculature, and if genotypes can predict skeletal growth.
MATERIALS AND METHODS
A prospective study on 42 patients over 1 year was performed. The study included 22 females and 20 males with and average age of 28.5 years. Lip strength was compared to radiographic cephalometric measurements. Allelic and genotypic frequencies from polymorphisms rs678397 and rs1815739 in ACTN3 and rs10850110 in MYO1H were compared to each variable. Chi-square and Fisher exact tests were used to determine if differences were statistically significant (alpha = 0.05).
RESULTS
The data showed significant differences between rs678397 genotype and allele frequencies and SNA angle (P = .01; P = .003, respectively); between rs1815739 allele frequency and SNA angle (P = .01); between rs678397 allele frequency and ANB angle (P = .049); between rs678397 genotype and allele frequencies and lip strength in females (P = .045; P = .02); and between rs678397 allele frequency and overall lip strength (P = .049), after mean strength values used as cut off being customized by sex.
CONCLUSIONS
Polymorphisms in ACTN3 are associated with weak lips and larger SNA and ANB angles.
目的
确定颌骨骨骼位置与口周肌肉组织之间是否存在关联，以及基因类型能否预测骨骼生长。
材料与方法
对42例患者进行了为期1年以上的前瞻性研究。该研究纳入了22名女性和20名男性，平均年龄为28.5岁。将唇部力量与头颅侧位X线测量结果进行比较。将ACTN3基因多态性rs678397和rs1815739以及MYO1H基因多态性rs10850110的等位基因和基因型频率与每个变量进行比较。采用卡方检验和Fisher精确检验来确定差异是否具有统计学意义（α = 0.05）。
结果
数据显示，rs678397基因型和等位基因频率与SNA角之间存在显著差异（分别为P = 0.01；P = 0.003）；rs1815739等位基因频率与SNA角之间存在显著差异（P = 0.01）；rs678397等位基因频率与ANB角之间存在显著差异（P = 0.049）；rs678397基因型和等位基因频率与女性唇部力量之间存在显著差异（分别为P = 0.045；P = 0.02）；在根据性别对平均力量值进行定制作为临界值后，rs678397等位基因频率与总体唇部力量之间存在显著差异（P = 0.049）。
结论
ACTN3基因多态性与唇部力量薄弱以及较大的SNA和ANB角相关。
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