Department of Radiation Oncology, Washington University School of Medicine in St Louis, St Louis, MO.
Department of Engineering Management and Systems Engineering, Missouri University of Science and Technology, Rolla, MO.
JCO Glob Oncol. 2022 May;8:e2100284. doi: 10.1200/GO.21.00284.
Disparities in radiation oncology (RO) can be attributed to geographic location, socioeconomic status, race, sex, and other societal factors. One potential solution is to implement a fully mobile (FM) RO system to bring radiotherapy to rural areas and reduce barriers to access. We use Monte Carlo simulation to quantify techno-economic feasibility with uncertainty, using two rural Missouri scenarios.
Recently, a semimobile RO system has been developed by building an o-ring linear accelerator (linac) into a mobile coach that is used for temporary care, months at a time. Transitioning to a more FM-RO system, which changes location within a given day, presents technical challenges including logistics and quality assurance. This simulation includes cancer census in both northern and southeastern Missouri, multiple treatment locations within a given day, and associated expenditures and revenues. A subset of patients with lung, breast, and rectal diseases, treated with five fractions, was simulated in the FM-RO system.
The FM-RO can perform all necessary quality assurance tests as suggested in national medical physics guidelines within 1.5 hours, thus demonstrating technological feasibility. In northern and southeastern Missouri, five-fraction simulations' net incomes were, in US dollars (USD), $1.55 ± 0.17 million (approximately 74 patients/year) and $3.65 USD ± 0.25 million (approximately 98 patients/year), respectively. The number of patients seen had the highest correlation with net income as well as the ability to break-even within the simulation. The model does not account for disruptions in care or other commonly used treatment paradigms, which may lead to differences in estimated economic return. Overall, the mobile system achieved a net benefit, even for the most negative simulation scenarios.
Our simulations suggest technologic success and economic viability for a FM-RO system within rural Missouri and present an interesting solution to address other geographic disparities in access to radiotherapy.
放射肿瘤学(RO)的差异可归因于地理位置、社会经济地位、种族、性别和其他社会因素。一种潜在的解决方案是实施完全移动(FM)RO 系统,将放射治疗带到农村地区,减少获得治疗的障碍。我们使用蒙特卡罗模拟来量化技术经济可行性及其不确定性,使用密苏里州的两个农村场景进行研究。
最近,通过将 O 型环直线加速器(linac)构建到移动教练中,开发了一种半移动 RO 系统,该系统用于临时护理,每次使用数月。向更具 FM-RO 系统的过渡,即每天在不同地点转换,会带来技术挑战,包括物流和质量保证。该模拟包括密苏里州北部和东南部的癌症普查、每天在多个治疗地点进行治疗,以及相关的支出和收入。模拟了一组患有肺癌、乳腺癌和直肠癌的患者,这些患者接受了五次分割治疗。
FM-RO 可以按照国家医学物理指南的建议,在 1.5 小时内完成所有必要的质量保证测试,从而证明了技术可行性。在密苏里州北部和东南部,五次分割模拟的净收入分别为 155 万美元(约 74 例/年)和 3650 万美元(约 98 例/年)。患者数量与净收入以及在模拟中收支平衡的能力相关性最高。该模型未考虑治疗中断或其他常用的治疗模式,这可能会导致对经济回报的估计存在差异。总体而言,即使在最不利的模拟场景下,移动系统也实现了净收益。
我们的模拟表明,在密苏里州农村地区,FM-RO 系统具有技术成功和经济可行性,并为解决其他地理上放疗获得性差异提供了一个有趣的解决方案。