核糖体碰撞：核糖体救援的新途径。
Ribosome collisions: New ways to initiate ribosome rescue.
机构信息
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
出版信息
Curr Biol. 2022 May 23;32(10):R469-R472. doi: 10.1016/j.cub.2022.04.038.
Abstract
When ribosomes collide while translating the same mRNA, a MutS-like protein can pry apart the leading ribosome and a nuclease can cut the mRNA between the collided ribosomes to initiate ribosome rescue and recycling.
摘要
当核糖体在翻译同一 mRNA 时发生碰撞时，一种类似于 MutS 的蛋白质可以将领先的核糖体拉开，而核酸内切酶可以在碰撞的核糖体之间切割 mRNA，从而启动核糖体救援和回收。
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