HSP60 在癌症中的多重作用和治疗潜力。

The multiple roles and therapeutic potential of HSP60 in cancer.

机构信息

Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

出版信息

Biochem Pharmacol. 2022 Jul;201:115096. doi: 10.1016/j.bcp.2022.115096. Epub 2022 May 21.

DOI:10.1016/j.bcp.2022.115096

Abstract

The molecular chaperone protein HSP60 is mainly distributed in mitochondria and assists protein folding under physiological and pathological conditions. Accumulating evidence suggests abnormally expressed HSP60 in cancer is associated with clinicopathological features and prognosis of cancer patients. HSP60 could be used as a new biomarker for both diagnostic and prognostic purpose and tumor therapy. In this review article, we briefly described the structure, functional cycle, and regulatory mechanism of HSP60, and summarized its functional diversity in cancer as well as recent progress related to the diagnostic application of HSP60 and inhibitors against HSP60, which could provide us a comprehensive understanding about the value of HSP60 in tumor management.

摘要

热休克蛋白 60（HSP60）是一种分子伴侣蛋白，主要分布在线粒体中，在生理和病理条件下协助蛋白质折叠。越来越多的证据表明，癌症中异常表达的 HSP60 与癌症患者的临床病理特征和预后相关。HSP60 可以作为一种新的生物标志物，用于诊断和预后目的以及肿瘤治疗。在这篇综述文章中，我们简要描述了 HSP60 的结构、功能循环和调节机制，并总结了其在癌症中的功能多样性以及与 HSP60 的诊断应用和 HSP60 抑制剂相关的最新进展，这可以让我们全面了解 HSP60 在肿瘤管理中的价值。