Babraham Research Campus, The Babraham Institute, Cambridge CB22 3AT, United Kingdom.
Babraham Research Campus, The Babraham Institute, Cambridge CB22 3AT, United Kingdom; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), INSERM UMR1291, CNRS UMR, Toulouse 5051, France.
Immunol Lett. 2022 Jul;247:22-26. doi: 10.1016/j.imlet.2022.05.004. Epub 2022 May 21.
CD4Foxp3 Regulatory T cells (Tregs) are essential for maintaining self-tolerance and are increasingly recognised to have important roles in tissue homeostasis and repair. In the CD8 compartment an analogous Foxp3 population is present, which shares phenotypic aspects with the more common CD4Foxp3Treg population. While oft neglected for their low frequency, there is increasing evidence that these CD8Foxp3 cells are bona fide regulatory cells, with both shared and distinct characteristics from their CD4 analogue. Here we focus on the evidence for a regulatory function of CD8Foxp3 cells, and the potential unique role this neglected lineage may play in immune homeostasis and disease prevention.
CD4+Foxp3+ 调节性 T 细胞（Tregs）对于维持自身耐受至关重要，并且越来越多地被认为在组织稳态和修复中具有重要作用。在 CD8 区室中存在类似的 Foxp3 群体，其表型方面与更为常见的 CD4+Foxp3+Treg 群体相似。虽然由于其频率较低而经常被忽视，但越来越多的证据表明这些 CD8+Foxp3 细胞是真正的调节细胞，与它们的 CD4 类似物具有共同和独特的特征。在这里，我们重点介绍 CD8+Foxp3 细胞的调节功能的证据，以及这一被忽视的谱系在免疫稳态和疾病预防中可能发挥的独特作用。
