Nolan A, Livingston A, Morris R, Waterman A
J Pharmacol Methods. 1987 Mar;17(1):39-49. doi: 10.1016/0160-5402(87)90035-0.
The assessment of analgesia in conscious unrestrained farm animals presents particular problems. In order to provide a reliable nociceptive stimulus, two devices have been constructed, one that provides a threshold reading for a ramped thermal stimulus of the pinna of the ear and another that measures a threshold reading for a pressure stimulus to the foreleg. Both devices allow the rapid termination of the stimulus once a reaction has occurred and allow repeated readings without causing tissue damage. Examples of the analgesic action of alpha 2-adrenoceptor agonists and opioids measured by using the two pieces of apparatus are shown.
对清醒且未受限制的农场动物进行镇痛评估存在特殊问题。为了提供可靠的伤害性刺激，已构建了两种装置，一种用于提供耳部耳廓斜坡热刺激的阈值读数，另一种用于测量前腿压力刺激的阈值读数。一旦发生反应，这两种装置都能迅速终止刺激，并能进行重复读数而不会造成组织损伤。展示了使用这两种仪器测量的α2-肾上腺素能受体激动剂和阿片类药物的镇痛作用实例。
