Departments of Medicine, Obstetrics and Gynecology, and Epidemiology, University of Michigan, Ann Arbor, Michigan.
School of Kinesiology, University of British Columbia, Vancouver, Canada.
Fertil Steril. 2022 Jul;118(1):125-133. doi: 10.1016/j.fertnstert.2022.03.021. Epub 2022 May 21.
To examine whether premenopausal reproductive age, as indicated by serum antimüllerian hormone (AMH), is associated with leukocyte aging biomarkers.
Prospective cohort analysis.
The Coronary Artery Risk Development in Young Adults study, a population-based study of Black and White adults from four US communities (Birmingham, AL; Chicago, IL; Minneapolis, MN; Oakland, CA).
PATIENT(S): Premenopausal women with serum AMH measures at examination year 15 as well as leukocyte aging markers.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Telomere length, mitochondrial deoxyribonucleic acid (mtDNA) copy number, and intrinsic and extrinsic epigenetic age acceleration (EAA) at examination years 15, 20, and 25 as well as change between examination years.
RESULT(S): Women were 40.2 (standard deviation, 3.7) years of age at examination year 15 when the AMH and initial measures of telomere length and mtDNA copy number (n = 386) were obtained and EAA occurred. After adjustment for chronological age, race, and smoking history, AMH quartile at examination year 15 was not associated with telomere length at examination years 15 and 25 or telomere length change between these years, mtDNA copy number at examination years 15 and 25 or change between these years, or intrinsic EAA at examination years 15 and 20 or change between these years. Women in the second AMH quartile had faster extrinsic EAA than women in the lowest AMH quartile (β-coefficient, 1.84; 95% confidence interval, 0.20-3.49).
CONCLUSION(S): In a population-based cohort, AMH did not have associations with leukocyte telomere length, mtDNA copy number, or intrinsic EAA.
检测血清抗苗勒管激素（AMH）所指示的绝经前育龄期是否与白细胞衰老生物标志物相关。
前瞻性队列分析。
冠状动脉风险发展在年轻人研究，这是一个基于人群的研究，来自美国四个社区（伯明翰，阿拉巴马州;芝加哥，伊利诺伊州;明尼阿波利斯，明尼苏达州;奥克兰，加利福尼亚州）的黑人和白人成年人。
在检查年度 15 时具有血清 AMH 测量值以及白细胞衰老标志物的绝经前妇女。
无。
端粒长度、线粒体脱氧核糖核酸（mtDNA）拷贝数以及在检查年度 15、20 和 25 时的内在和外在表观遗传年龄加速（EAA）以及检查年度之间的变化。
在检查年度 15 时，当获得 AMH 和初始端粒长度和 mtDNA 拷贝数测量值（n = 386）以及 EAA 发生时，女性年龄为 40.2（标准差，3.7）岁。在调整了年龄、种族和吸烟史后，检查年度 15 时的 AMH 四分位数与检查年度 15 和 25 时的端粒长度或这些年之间的端粒长度变化、检查年度 15 和 25 时的 mtDNA 拷贝数或这些年之间的变化、或检查年度 15 和 20 时的内在 EAA 或这些年之间的变化均无关联。与最低 AMH 四分位数的女性相比，第二 AMH 四分位数的女性的外在 EAA 更快（β系数，1.84;95%置信区间，0.20-3.49）。
在基于人群的队列中，AMH 与白细胞端粒长度、mtDNA 拷贝数或内在 EAA 没有关联。
