Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Microbiology, New York University, Langone Health, New York, NY, USA.
Nat Rev Immunol. 2022 Jul;22(7):399-400. doi: 10.1038/s41577-022-00739-8.
Large-scale clinical studies on the post-infectious impacts of SARS-CoV-2 have suggested that patients who have recovered from acute infection have increased risk for cardiometabolic syndrome-associated morbidities such as diabetes, chronic kidney disease and heart failure. Initial studies have taken the first steps towards unravelling the molecular processes that may be driving these findings, including the role of immune and inflammatory factors, but a comprehensive aetiology remains unclear. Given that cardiometabolic syndrome progression in patients with Long COVID may pose a significant global health and economic burden post pandemic, there is an emergent need to identify therapeutic targets and treatment options.
大规模的临床研究表明,SARS-CoV-2 感染后会对患者产生影响,使急性感染康复者罹患糖尿病、慢性肾脏病和心力衰竭等代谢综合征相关疾病的风险增加。最初的研究已经朝着揭示可能导致这些发现的分子过程迈出了第一步,包括免疫和炎症因素的作用,但全面的病因仍不清楚。鉴于长新冠患者的代谢综合征进展可能在大流行后对全球健康和经济造成重大负担,因此迫切需要确定治疗靶点和治疗选择。