Rehabilitation Department, Hefei BOE Hospital of BOE Technology Group, Hefei, Anhui Province, 230011, PR China.
Traditional Chinese Medicine Department, Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 211100, PR China.
Spinal Cord. 2022 Nov;60(11):1006-1013. doi: 10.1038/s41393-022-00814-w. Epub 2022 May 24.
Cross-sectional study.
To elucidate the association between age and incidence of deep vein thrombosis (DVT) in patients with spinal cord injury (SCI).
Rehabilitation Medicine Department of the First Affiliated Hospital of China University of Science and Technology.
Patients from August 2018 to December 2020 with SCI (N = 260) were tertiles divided the age into three groups to analyze the association between age and incidence of DVT.
American Spinal Cord Injury Association impairment scale (AIS), urinary tract infection (UTI), pulmonary infection (PI), and anticoagulation therapy (AT) were confounders for the association between age and incidence of DVT. The incidence of DVT increased by 1.07-fold (Non-adjusted model, OR = 1.07, P < 0.001), 1.05-fold (Minimally-adjusted model: adjusted for confounders, OR = 1.05, P = 0.010) and 1.06-fold [Fully-adjusted model: adjusted for confounders and unbalanced probable variables: AIS, UTI, PI, AT, Sex, D-dimer(new), Fibrinogen (new), Modes of injury and Level of injury, OR = 1.06, P = 0.012] when age increased by 1 year. The incidence of DVT had an increasing trend with age in different age tertile in the three models (P for trend <0.05). Age had a linearly association with incidence of DVT (OR = 1.07, P = 0.065) and stable in different subgroups, for lower age, the association was also linearly (OR = 4.40, P = 1.000), for middle (fold point = 46.46, P < 0.001) and higher age (fold point = 66, P = 0.017), the association was curvilinear.
Age had a linearly association with incidence of DVT. Quitting smoking, preventing/treating UTI and AT should be adopted in advance for patients with SCI for all age, especially for older.
横断面研究。
阐明脊髓损伤（SCI）患者年龄与深静脉血栓形成（DVT）发生率之间的关系。
中国科学技术大学第一附属医院康复医学科。
将 2018 年 8 月至 2020 年 12 月的 SCI 患者（N=260）按年龄分为三组，分析年龄与 DVT 发生率之间的关系。
美国脊髓损伤协会损伤量表（AIS）、尿路感染（UTI）、肺部感染（PI）和抗凝治疗（AT）是年龄与 DVT 发生率之间关系的混杂因素。DVT 的发生率增加了 1.07 倍（非调整模型，OR=1.07，P<0.001）、1.05 倍（最小调整模型：调整混杂因素，OR=1.05，P=0.010）和 1.06 倍[完全调整模型：调整混杂因素和不平衡的可能变量：AIS、UTI、PI、AT、性别、D-二聚体（新）、纤维蛋白原（新）、损伤方式和损伤水平，OR=1.06，P=0.012]，年龄增加 1 岁。在三个模型中，不同年龄组的 DVT 发生率随年龄呈上升趋势（趋势 P<0.05）。年龄与 DVT 的发生率呈线性关系（OR=1.07，P=0.065），在不同亚组中稳定，对于低年龄组，这种关系也是线性的（OR=4.40，P=1.000），对于中年龄组（转折点=46.46，P<0.001）和高年龄组（转折点=66，P=0.017），这种关系是曲线的。
年龄与 DVT 的发生率呈线性关系。对于所有年龄的 SCI 患者，尤其是年龄较大的患者，应提前戒烟、预防/治疗 UTI 和 AT。
