年龄校正后的D-二聚体值在预测膝关节和髋关节置换术前深静脉血栓形成方面的表现。
Performance of age-adjusted D-dimer values for predicting DVT before the knee and hip arthroplasty.
作者信息
Wu Jian Xiang, Qing Jiang Hui, Yao Yao, Chen Dong Yang, Jiang Qing
机构信息
Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, P.R. China.
State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, P.R. China.
出版信息
J Orthop Surg Res. 2021 Jan 25;16(1):82. doi: 10.1186/s13018-020-02172-w.
PURPOSE
To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients.
METHODS
We enrolled 406 patients finally above 50 years old. Everyone had done ultrasonography bedside, and D-dimer concentrations were collected before surgery. The D-dimer and age-adjusted D-dimer cut-off was calculated by multiple logistic regression and receiver operating curve (ROC) analyses.
RESULTS
A total of 39 patients had found asymptomatic deep vein thrombosis (DVT) by ultrasonography. The age (odds ratio [OR] 1.067; p = 0.003) and D-dimer (OR 1.331; p = 0.025) were related to the existence of DVT. For conventional D-dimer and age-adjusted D-dimer value, the area under the curves (AUCs) were 0.685 (0.499-0.696) and 0.795 (0.611-0.881), respectively.
CONCLUSION
Compared to traditional D-dimer, age-adjusted D-dimer showed better performance in screening DVT, which was useful clinically.
目的
比较术前D - 二聚体和年龄校正后的D - 二聚体值在预测全关节置换术（TJA）患者术前深静脉血栓形成（DVT）发生率方面的特异性和敏感性。
方法
我们最终纳入了406例年龄在50岁以上的患者。每位患者均接受了床边超声检查，并在手术前采集了D - 二聚体浓度。通过多元逻辑回归和受试者工作特征曲线（ROC）分析计算D - 二聚体和年龄校正后的D - 二聚体临界值。
结果
共有39例患者通过超声检查发现无症状深静脉血栓形成（DVT）。年龄（比值比[OR] 1.067；p = 0.003）和D - 二聚体（OR 1.331；p = 0.025）与DVT的存在相关。对于传统D - 二聚体和年龄校正后的D - 二聚体值，曲线下面积（AUC）分别为0.685（0.499 - 0.696）和0.795（0.611 - 0.881）。
结论
与传统D - 二聚体相比，年龄校正后的D - 二聚体在筛查DVT方面表现更好，具有临床应用价值。
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