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[色谱 - 质谱仪在诊断中的应用]

[Use of chromatographic-mass spectrometers in diagnosis].

作者信息

Dmitriev M T, Malysheva A G, Rastiannikov E G

出版信息

Med Tekh. 1987 Jan-Feb(1):17-22.

PMID:3561216
Abstract

Conditions for extraction, desorption and concentration of specific substances, such as metabolites, and characteristics of their gas-chromatographic division and mass-spectrometric identification have been established. A library for mass-spectra of specific metabolite compounds characteristic of various diseases has been set up. Computer programs for metabolite analysis and for diagnosis were modified. An experimental introduction of chromatographic-mass-spectrometric diagnosis into practice in a number of hospitals and research institutions for prophylactic medical examination of people will make it possible to quickly accumulate statistic data and create the necessary data bank.

摘要

已经确定了特定物质(如代谢物)的提取、解吸和浓缩条件,以及它们的气相色谱分离和质谱鉴定特征。建立了一个包含各种疾病特征性特定代谢物化合物质谱的库。修改了用于代谢物分析和诊断的计算机程序。在一些医院和研究机构将色谱 - 质谱诊断实验性地应用于人群预防性医学检查实践,将能够快速积累统计数据并创建必要的数据库。

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