Hbibi Abdelhadi, Bouziane Amal, Lyoussi Badiaa, Zouhdi Mimoun, Benazza Driss
Research laboratory in oral biology and biotechnology, Faculty of dental medicine, Mohammed V University in Rabat, Rabat, Morocco.
Centre des Soins Dentaires, Hôpital Provincial Moulay Abdellah, Salé, Morocco.
Adv Exp Med Biol. 2022;1373:45-67. doi: 10.1007/978-3-030-96881-6_3.
Aggregatibacter actinomycetemcomitans is a major periodontal pathogen that was identified firstly in actinomycotic lesions and later in advanced forms of periodontal diseases as well as in oral cavity of healthy subjects. The particular pathogenicity of this specie makes it a target for extensive studies both at fundamental and practical scales. The current advances in experimental and clinical research related to this bacterium focus the light on epidemiologic features, virulence, and invasiveness aspects as well as on identification challenges, bacterial susceptibility, and anti-virulence strategies. The present chapter provide to scientists and periodontal researchers a comprehensive overview on the main advances made in this field with a special focus on epidemiologic dissemination, microbial diagnosis, virulence factors and clinical implementations of such progress.
伴放线聚集杆菌是一种主要的牙周病原体，最初在放线菌病病变中被发现，后来在晚期牙周疾病以及健康受试者的口腔中也被发现。该菌种独特的致病性使其成为基础和实践层面广泛研究的对象。与这种细菌相关的实验和临床研究的当前进展聚焦于流行病学特征、毒力和侵袭性方面，以及鉴定挑战、细菌易感性和抗毒力策略。本章为科学家和牙周病研究人员提供了该领域主要进展的全面概述，特别关注流行病学传播、微生物诊断、毒力因子以及这些进展的临床应用。
