Department of Cardiology, Saidu Teaching Hospital Saidu Sharif, Swat, Pakistan.
Department of Cardiology, Punjab Institute of Cardiology, Lahore, Pakistan.
Expert Rev Cardiovasc Ther. 2022 Jun;20(6):465-479. doi: 10.1080/14779072.2022.2082945. Epub 2022 Jun 2.
Dengue is one of the most important viral diseases globally and a majority of symptomatic infections result in a benign course. However, a small number of patients develop severe manifestations, including the cardiovascular (CV) manifestations, including myocardial impairment, arrhythmias, and fulminant myocarditis.
Electronic databases, including PubMed/MEDLINE, EMBASE, Scopus, and CINAHL were searched for articles incorporating CV manifestations of dengue fever (DF).
Included studies involved 6,773 patients, and 3,122 (46.1%) exhibited at least one cardiac manifestation. Electrocardiogram (ECG) abnormalities (30.6%) included sinus bradycardia (8.8%), nonspecific ST-T changes (8.6%), ST depression (7.9%), and T-wave inversion (2.3%). Mechanical sequelae were present in 10.4%, including left ventricular (LV) systolic dysfunction (5.7%), and myocarditis (2.9%). Pericardial involvement was noted as pericarditis (0.1%), pericardial effusion (1.3%), and pericardial tamponade (0.1%). Apart from that, the cardiac injury was depicted through a rise in cardiac enzymes (4.5%). The spectrum of CV manifestations in dengue is broad, ranging from subtle ST-T changes to fulminant myocarditis and the use of contemporary techniques in diagnosing cardiac involvement should be employed for rapid diagnosis and treatment.
登革热是全球最重要的病毒性疾病之一，大多数有症状的感染呈良性过程。然而，少数患者会出现严重的表现，包括心血管（CV）表现，包括心肌损伤、心律失常和暴发性心肌炎。
电子数据库，包括 PubMed/MEDLINE、EMBASE、Scopus 和 CINAHL，用于搜索包含登革热（DF）CV 表现的文章。
纳入的研究涉及 6773 名患者，其中 3122 名（46.1%）至少有一个心脏表现。心电图（ECG）异常（30.6%）包括窦性心动过缓（8.8%）、非特异性 ST-T 改变（8.6%）、ST 段压低（7.9%）和 T 波倒置（2.3%）。机械后遗症发生率为 10.4%，包括左心室（LV）收缩功能障碍（5.7%）和心肌炎（2.9%）。心包受累表现为心包炎（0.1%）、心包积液（1.3%）和心包填塞（0.1%）。除此之外，还通过心肌酶升高（4.5%）来描述心脏损伤。登革热的 CV 表现谱广泛，从细微的 ST-T 改变到暴发性心肌炎，应采用现代技术诊断心脏受累，以便快速诊断和治疗。
