光控PISA：揭示聚合诱导自组装
Photo-PISA: Shedding Light on Polymerization-Induced Self-Assembly.
作者信息
Tan Jianbo, Sun Hao, Yu Mingguang, Sumerlin Brent S, Zhang Li
机构信息
Department of Polymeric Materials and Engineering, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.
George and Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science and Engineering, Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, Florida, United States.
出版信息
ACS Macro Lett. 2015 Nov 17;4(11):1249-1253. doi: 10.1021/acsmacrolett.5b00748. Epub 2015 Oct 26.
Herein we report an aqueous photoinitiated polymerization-induced self-assembly (photo-PISA) for the preparation of a remarkably diverse set of complex polymer nanoparticle morphologies (e.g., spheres, worms, and vesicles) at room temperature. Ultrafast polymerization rates were achieved, with near quantitative monomer conversion within 15 min of visible light irradiation. An important feature of the photo-PISA is that diblock copolymer vesicles can be prepared under mild conditions (room temperature, aqueous medium, visible light), which will be important for the preparation of functional vesicles loaded with biorelated species (e.g., proteins). As a proof of concept, silica nanoparticles and bovine serum albumin (BSA) were encapsulated in situ within vesicles via the photo-PISA process.
在此，我们报道了一种水性光引发聚合诱导自组装（光引发PISA）方法，用于在室温下制备一系列形态极为多样的复杂聚合物纳米颗粒（例如球形、蠕虫状和囊泡状）。实现了超快的聚合速率，在可见光照射15分钟内单体转化率接近定量。光引发PISA的一个重要特点是可以在温和条件下（室温、水性介质、可见光）制备二嵌段共聚物囊泡，这对于制备负载生物相关物质（如蛋白质）的功能性囊泡具有重要意义。作为概念验证，通过光引发PISA过程将二氧化硅纳米颗粒和牛血清白蛋白（BSA）原位封装在囊泡中。
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