3 例晚期人类免疫缺陷病毒-1 病患者中 B.1.1.7 谱系新型严重急性呼吸综合征冠状病毒 2 变异株的产生。
Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease.
机构信息
Virology Department, Division of Infection, Barts Health NHS Trust, London, United Kingdom.
Department of Infection and Immunity, Barts Health NHS Trust, London, United Kingdom.
出版信息
Clin Infect Dis. 2022 Nov 30;75(11):2016-2018. doi: 10.1093/cid/ciac409.
Abstract
The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape.
摘要
新的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）变种的出现，如果疫苗逃逸，将引起公共卫生关注。本文描述了 3 例晚期人类免疫缺陷病毒（HIV-1）合并慢性 SARS-CoV-2 感染患者，他们体内存在与传染性增加和免疫逃逸相关的新型突变的选择和持续存在的证据。
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