Laboratory of Neuroepigenetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale Lausanne (EPFL-EPFL-SV-BMI-UPGRAEFF), Station 19, Lausanne, Switzerland.
Cogn Neurosci. 2022 Jul;13(3-4):134-136. doi: 10.1080/17588928.2022.2076075. Epub 2022 May 26.
Where memories are stored in the brain is an age-old question in psychology and neuroscience alike. In particular, whether hippocampus-encoded memories are transferred to the cortex or remain hippocampus-dependent over time has not been definitely answered. New evidence from fMRI studies in humans suggest that while hippocampo-cortical connections lose weight during declarative memory consolidation, the hippocampus - alongside corticocortical connections - stays equally engaged between recent and remote memory recall. These findings lend experimental support for the indexing theory of memory consolidation, which postulates the hippocampus to act as a librarian to retrieve the cortical books of memory.
记忆在大脑中的存储位置是心理学和神经科学领域的一个古老问题。特别是，海马体编码的记忆是随着时间的推移转移到大脑皮层还是仍然依赖于海马体，这个问题尚未得到明确回答。来自人类 fMRI 研究的新证据表明，虽然在陈述性记忆巩固过程中海马-皮质连接体的权重会减轻，但海马体——与皮质-皮质连接体一起——在最近和遥远的记忆回忆之间保持同样的活跃状态。这些发现为记忆巩固的索引理论提供了实验支持，该理论假设海马体充当图书管理员，以检索记忆的皮质书籍。
