Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mini Rev Med Chem. 2023;23(6):756-770. doi: 10.2174/1389557522666220523112027.
Neurodegenerative Diseases (NDs) are characterized by progressive neuronal deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including sesamin with multitarget activities, have been studied widely.
In this review, we aim to survey the neuroprotective effects of sesamin on NDs and its mechanisms of action.
Searching GoogleScholar, PubMed, and Science Direct databases, we reviewed original English language articles on sesamin effects against NDs, specifically Alzheimer's Disease (AD) and Parkinson's Disease (PD), either in vivo or in vitro settings, with no time limitation.
Sesamin has been reported to interfere with NDs progression through its antioxidative, antiinflammatory, and antiapoptotic actions in most of the retrieved studies. Sesamin also can prevent amyloid-β aggregation in AD models and elevate dopamine levels in PD-induced models.
The results of this study revealed the beneficial effects of sesamin in the prevention and management of NDs, including AD and PD; however, no clinical data supporting these effects in humans is available, which highlights the need for designing clinical trials to evaluate the efficacy, proper dosage, pharmacokinetics aspects, and possible side effects of sesamin in humans.
神经退行性疾病（NDs）的特征是由于多种发病机制导致神经元进行性恶化。植物化学物质，包括具有多种靶点活性的芝麻素，已被广泛研究。
在这篇综述中，我们旨在调查芝麻素对 NDs 的神经保护作用及其作用机制。
通过在 Google Scholar、PubMed 和 Science Direct 数据库中进行搜索，我们回顾了有关芝麻素对 NDs 的作用的原始英文文献，特别是针对阿尔茨海默病（AD）和帕金森病（PD）的体内和体外研究，没有时间限制。
在大多数检索到的研究中，芝麻素通过其抗氧化、抗炎和抗细胞凋亡作用被报道可以干扰 NDs 的进展。芝麻素还可以预防 AD 模型中的淀粉样β聚集，并提高 PD 诱导模型中的多巴胺水平。
这项研究的结果表明芝麻素在预防和管理 NDs，包括 AD 和 PD 方面具有有益的作用；然而，目前尚无支持这些作用的人体临床数据，这凸显了设计临床试验以评估芝麻素在人体中的疗效、适当剂量、药代动力学方面和可能的副作用的必要性。
