Baskin S, Bartuska D, Thampi N, McBride M, Finnigan J
Neuropeptides. 1987 Jan;9(1):45-50. doi: 10.1016/0143-4179(87)90031-x.
Glutaurine (gamma-L-glutamyl taurine), a proposed hormone isolated from parathyroid gland oxyphil cells, was examined for its effect on circulating thyroid hormones in the rat. In acute experiments performed over a 24 hr. period, glutaurine depressed plasma triiodothyronine (T3) levels in a dose-dependent manner; however, thyroxine (T4) levels were not affected significantly. In chronic experiments performed over a 2 wk. period, glutaurine significantly increased T3 levels, but, as with acute studies, the effect of T4 levels was not significantly altered. Following acute glutaurine administration, TSH levels were elevated above control. The increased T3 observed following chronic glutaurine administration may be due to a secondary increase in TSH levels. These data support the hypothesis that glutaurine aids in peripheral thyroid hormonal regulation. Observed differences between acute and chronic glutaurine action are though to result from the effect of glutaurine on the negative feedback inhibiting action of TSH.
谷氨酰胺（γ-L-谷氨酰牛磺酸）是一种从甲状旁腺嗜酸性细胞中分离出来的疑似激素，研究了其对大鼠循环甲状腺激素的影响。在为期24小时的急性实验中，谷氨酰胺以剂量依赖的方式降低血浆三碘甲状腺原氨酸（T3）水平；然而，甲状腺素（T4）水平未受到显著影响。在为期2周的慢性实验中，谷氨酰胺显著提高了T3水平，但与急性研究一样，T4水平的影响没有显著改变。急性给予谷氨酰胺后，促甲状腺激素（TSH）水平升高至对照组之上。慢性给予谷氨酰胺后观察到的T3增加可能是由于TSH水平的继发性升高。这些数据支持了谷氨酰胺有助于外周甲状腺激素调节的假说。急性和慢性谷氨酰胺作用之间观察到的差异被认为是由谷氨酰胺对TSH负反馈抑制作用的影响所致。
