Dimens Crit Care Nurs. 2022;41(4):190-199. doi: 10.1097/DCC.0000000000000529.
Factor V Leiden (FVL) is a hereditary thrombophilia, which causes the blood to be more hypercoagulable; in essence, the blood tends to clot more easily, especially under certain circumstances. It is the most common genetic mutation, causing thrombophilia in patients of white background. Patients that have FVL are at a higher risk to develop venous thromboembolism (VTE) after surgery and trauma.
The purpose of this review is to identify FVL as a risk factor, which may impede optimum acute cardiopulmonary management which may contribute to a longer length of stay (LOS) in the hospital.
This article is a systematic review of the literature involving research printed in peer-reviewed journals from 2015 to 2018. The University of Tennessee Health Science Center online library, PubMed, and Google Scholar were used for the literature search.
The results of this study determined that although FVL is in fact a risk factor, which may impede optimum acute cardiopulmonary management which may contribute to a longer LOS, management of VTE is no different for a person with FVL compared with those without FVL.
Factor V Leiden is a risk factor for the development of VTE, specifically deep vein thrombosis, in surgical, trauma, pregnant, and hormone replacement therapy patients, thus increasing LOS and recurrence of such events. Regardless of FVL status, management of VTE should be initiated promptly and discontinued when appropriate.
因子 V 莱顿突变（Factor V Leiden，FVL）是一种遗传性血栓形成倾向，可导致血液更加容易凝结；从本质上讲，血液在某些情况下更容易凝结。它是导致白种人背景患者血栓形成倾向的最常见基因突变。患有 FVL 的患者在手术后和创伤后发生静脉血栓栓塞症（venous thromboembolism，VTE）的风险更高。
本综述的目的是确定 FVL 作为一个风险因素，可能会阻碍最佳的急性心肺管理，从而导致住院时间延长。
本文是对 2015 年至 2018 年发表在同行评议期刊上的文献进行的系统综述。田纳西大学健康科学中心在线图书馆、PubMed 和谷歌学术进行了文献检索。
本研究的结果表明，尽管 FVL 实际上是一个风险因素，可能会阻碍最佳的急性心肺管理，从而导致住院时间延长，但患有 FVL 的患者与没有 FVL 的患者的 VTE 管理并无不同。
因子 V 莱顿突变是手术、创伤、妊娠和激素替代治疗患者发生 VTE（特别是深静脉血栓形成）的一个风险因素，从而增加了 LOS 和此类事件的复发率。无论 FVL 状态如何，都应及时启动 VTE 的管理，并在适当的时候停止。
