Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China; Department of Early Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Aug 30;118:110578. doi: 10.1016/j.pnpbp.2022.110578. Epub 2022 May 23.
Emerging evidence suggested that people with severe mental disorders were more vulnerable to the negative effects of the COVID-19 pandemic. However, few researches investigated the influence of global pandemics on people at clinical high risk (CHR) for psychosis. This study aimed to investigate the impact of the COVID-19 pandemic on clinical symptoms, psychological distress, and eye-tracking characteristics in CHR individuals and healthy participants. Forty-nine CHR individuals and 50 healthy controls (HC) were assessed by PTSD Checklist for DSM-5 (PCL-5), Perceived Stress Scale, 10-item version (PSS-10), and Coronavirus Impact Scale (CIS). Eye movement performances were measured by the tests of fixation stability, free-viewing, and anti-saccade. According to the mean score of CIS, participants were stratified into high-impact (n = 35) and low-impact (n = 64) subgroups. Compared with the HC group, CHR participants reported significantly higher levels of post-traumatic symptoms caused by the COVID-19 pandemic and showed abnormalities in most of the eye movement indexes. Among the altered indexes, the saccade amplitude of fixation stability test (far distractor), the scan path length of free-viewing test, and the accuracy of anti-saccade test were negatively affected by the severity of impact level in the CHR group. Moreover, the altered eye movement indexes were significantly associated with the total scores of CIS, PCL-5, and subscales of the Scale of Prodromal Syndromes (SOPS) among CHR individuals. Overall, our findings suggested the negative impact of the COVID-19 pandemic on the eye movement characteristics of CHR individuals. The present study provides valuable information on physiological distress related to the COVID-19 pandemic and sensitive neuropsychological biomarkers that interacted with social and environment stress in the CHR population.
新出现的证据表明，患有严重精神障碍的人更容易受到 COVID-19 大流行的负面影响。然而，很少有研究调查全球大流行对精神病临床高危（CHR）人群的影响。本研究旨在调查 COVID-19 大流行对 CHR 个体和健康参与者的临床症状、心理困扰和眼动特征的影响。49 名 CHR 个体和 50 名健康对照者（HC）接受了 PTSD 检查表 DSM-5（PCL-5）、感知压力量表 10 项版（PSS-10）和冠状病毒影响量表（CIS）的评估。通过注视稳定性测试、自由观看测试和反扫视测试测量眼动表现。根据 CIS 的平均得分，将参与者分为高影响（n=35）和低影响（n=64）亚组。与 HC 组相比，CHR 参与者报告 COVID-19 大流行引起的创伤后症状明显更高，并且在大多数眼动指标上表现出异常。在改变的指标中，注视稳定性测试（远干扰）的扫视幅度、自由观看测试的扫描路径长度和反扫视测试的准确性均受到 CHR 组影响程度的负面影响。此外，在 CHR 个体中，改变的眼动指标与 CIS、PCL-5 和前驱症状量表（SOPS）的总分显著相关。总的来说，我们的研究结果表明 COVID-19 大流行对 CHR 个体的眼动特征产生了负面影响。本研究提供了与 COVID-19 大流行相关的生理困扰以及与 CHR 人群中的社会和环境压力相互作用的敏感神经心理学生物标志物的有价值信息。
