Huang Wei, Chen Chen, Chen Xianjun, Chen Xing, Gan Jingli, Zhu Xiquan, Xu Jian, Zhao Liqiong, Zhou Jie, Yang Rui, Lv Jing, Liu Xufeng, Li Hongzheng
Department of Psychiatry and Psychology, No. 923 Hospital of Joint Logistic Support Force of Chinese People's Liberation Army (PLA), No. 52 Zhiwu Road, Nanning, 530000, China.
Department of Military Medical Psychology, Air Force Medical University of PLA (the Fourth Military Medical University), No. 169 West Changle Road, Xi'an, 710032, China.
Asian J Psychiatr. 2021 Feb;56:102559. doi: 10.1016/j.ajp.2021.102559. Epub 2021 Jan 13.
Abnormalities of global visual scanning have been well-recognized in schizophrenia patients. However, its relevance to various cognitive domains is still understudied. In the present study, we identified the association between global visual scanning and cognitive function in schizophrenia.
Eye movement was captured and analyzed in 28 individuals with schizophrenia and 21 healthy controls in free viewing test. The MATRICS consensus cognitive battery (MCCB) was applied to evaluate cognitive function.
Consistent with previous reports, schizophrenia patients exhibited several eye movement abnormalities during global visual scanning and showed cognition deficits in MCCB test as compared with healthy controls. Fixation duration was significantly related to cognitive dysfunction in schizophrenia. Moreover, there was a potential that eye movement measures during landscape scanning, rather than face scanning, were preferentially related to cognitive dysfunction.
This study indicated the association between free visual scanning and various cognitive functions in schizophrenia, shedding light on the possibility that some eye movement measures during visual exploration could be a biomarker for cognitive deficits in schizophrenia.
精神分裂症患者的整体视觉扫描异常已得到充分认识。然而，其与各种认知领域的相关性仍未得到充分研究。在本研究中，我们确定了精神分裂症患者整体视觉扫描与认知功能之间的关联。
在自由观看测试中，对28例精神分裂症患者和21名健康对照者的眼动进行了捕捉和分析。应用MATRICS共识认知成套测验（MCCB）评估认知功能。
与先前报道一致，精神分裂症患者在整体视觉扫描过程中表现出多种眼动异常，并且与健康对照者相比，在MCCB测试中表现出认知缺陷。注视持续时间与精神分裂症患者的认知功能障碍显著相关。此外，有迹象表明，在风景扫描而非面部扫描过程中的眼动指标与认知功能障碍的相关性更为显著。
本研究表明了精神分裂症患者自由视觉扫描与各种认知功能之间的关联，揭示了视觉探索过程中的某些眼动指标可能是精神分裂症认知缺陷生物标志物的可能性。
