与草绿色链球菌相比，导致阿比奥特罗和颗粒链球菌感染性心内膜炎的临床特征和结局。

Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci.

机构信息

Hospital Clinic-IDIBAPS, Infectious Diseases Service, Hospital Clínic, University of Barcelona, Villarroel, 170, Barcelona 08036, Spain.

Hospital Clinic-IDIBAPS, Infectious Diseases Service, Hospital Clínic, University of Barcelona, Villarroel, 170, Barcelona 08036, Spain; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.

出版信息

J Infect. 2022 Aug;85(2):137-146. doi: 10.1016/j.jinf.2022.05.023. Epub 2022 May 23.

DOI:10.1016/j.jinf.2022.05.023

PMID:35618152

Abstract

OBJECTIVE

To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis.

METHODS

All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n = 8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. A propensity score (PS) analysis comparing the ABI/GRA-IE and VGS-IE groups according to a 1:2 ratio was performed.

RESULTS

Forty-eight (0.64%) cases of ABI/GRA-IE and 1,292 (17.2%) VGS-IE were included in the analysis. The median age of patients with ABI/GRA-IE was lower than VGS-IE (48.1 years vs. 57.9 years; p = 0.001). Clinical features and the rate of in-hospital surgery was similar between ABI/GRA-IE and VGS-IE (52.1% vs. 45.4%; p = 0.366). Unadjusted in-hospital death was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 8.8%; p = 0.003), and cumulative six-month mortality was lower in ABI/GRA-IE than VGS-IE (2.1% vs. 11.9%; p<0.001). After PS analysis, in-hospital mortality was similar in both groups, but six-month mortality was lower in the ABI/GRA IE group (2.1% vs. 10.4%; p = 0.029).

CONCLUSIONS

Patients with ABI/GRA-IE were younger, had similar clinical features and rates of surgery and better prognosis than VGS-IE.

摘要

目的

描述嗜养颗粒菌和金氏金菌感染性心内膜炎的临床特征和结局，并将其与草绿色链球菌感染性心内膜炎进行比较。

方法

纳入国际心内膜炎协作研究（ICE）前瞻性队列研究（PCS）和 ICE-PLUS 队列中的所有患者（n=8112）。分析了明确或可能由嗜养颗粒菌、金氏金菌和草绿色链球菌所致感染性心内膜炎患者的数据。根据 1:2 的比例，采用倾向评分（PS）分析比较 ABI/GRA-IE 和 VGS-IE 两组。

结果

48 例（0.64%）ABI/GRA-IE 和 1292 例（17.2%）VGS-IE 纳入分析。ABI/GRA-IE 患者的中位年龄低于 VGS-IE（48.1 岁 vs. 57.9 岁；p=0.001）。ABI/GRA-IE 和 VGS-IE 两组的临床特征和住院期间手术率相似（52.1% vs. 45.4%；p=0.366）。未校正的住院死亡率 ABI/GRA-IE 低于 VGS-IE（2.1% vs. 8.8%；p=0.003），ABI/GRA-IE 组的 6 个月累积死亡率也低于 VGS-IE（2.1% vs. 11.9%；p<0.001）。在 PS 分析后，两组的住院死亡率相似，但 ABI/GRA-IE 组的 6 个月死亡率较低（2.1% vs. 10.4%；p=0.029）。