Indovina I, Scaffidi A, Costa R
Minerva Med. 1987 Mar 31;78(6):369-72.
SeHCAT, a synthetic homologue of thaurocolic acid, may be used to examine the dynamics of enterohepatic circulation. A greater retention of SeHCAT may be attributed to a defective hepatic clearance and to a partial redistribution of the biliary acid pool outside the enterohepatic circle. This method has been applied to 20 patients affected with chronic hepatic disorders. The percentage of retention of SeHCAT in normal subjects was 19-20 on average. The hepatopathic patient has an average SeHCAT retention of 54%. After treatment with polyunsaturated phosphatidylcholine (EPL) plus vitamin B complex i.v., the percentage of SeHCAT retention was significantly less than 31% (P less than 0.001). It can be hypothesized that the drug determines an improvement of the enterohepatic circle (acting on the hepatic clearance) in patients with chronic hepatic disorders as shown by the reduction of the percentage of SeHCAT retention noticed.
硒同型胆酸（SeHCAT）是牛磺胆酸的合成类似物，可用于检测肠肝循环的动态变化。SeHCAT潴留增加可能归因于肝脏清除功能缺陷以及胆汁酸池在肠肝循环外的部分重新分布。该方法已应用于20例慢性肝脏疾病患者。正常受试者中SeHCAT的平均潴留率为19% - 20%。肝病患者的SeHCAT平均潴留率为54%。静脉注射多不饱和磷脂酰胆碱（EPL）加复合维生素B治疗后，SeHCAT的潴留率显著低于31%（P＜0.001）。可以推测，如所观察到的SeHCAT潴留率降低所示，该药物可改善慢性肝病患者的肠肝循环（作用于肝脏清除功能）。
