Hofseth Lorne J
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Coker Life Sciences, Room 513C, Columbia, SC 29208, USA.
Cancer Lett. 2008 Sep 8;268(1):10-30. doi: 10.1016/j.canlet.2008.03.024. Epub 2008 Apr 25.
Nitric oxide (NO) and associated reactive nitrogen species (RNS) are involved in many physiological functions. There has been an ongoing debate to whether RNS can inhibit or perpetuate chronic inflammation and associated carcinogenesis. Although the final outcome depends on the genetic make-up of its target, the surrounding microenvironment, the activity and localization of nitric oxide synthase (NOS) isoforms, and overall levels of NO/RNS, evidence is accumulating that in general, RNS drive inflammation and cancers associated with inflammation. To this end, many complementary and alternative medicines (CAMs) that work in chemoprevention associated with chronic inflammation, are inhibitors of excessive NO observed in inflammatory conditions. Here, we review recent literature outlining a role of NO/RNS in chronic inflammation and cancer, and point toward NO as one of several targets for the success of CAMs in treating chronic inflammation and cancer associated with this inflammation.
一氧化氮（NO）及相关活性氮物质（RNS）参与多种生理功能。关于RNS是能够抑制还是会促使慢性炎症及相关致癌作用持续存在，一直存在争论。尽管最终结果取决于其靶标的基因组成、周围微环境、一氧化氮合酶（NOS）同工型的活性和定位以及NO/RNS的总体水平，但越来越多的证据表明，一般而言，RNS会引发炎症以及与炎症相关的癌症。为此，许多用于与慢性炎症相关的化学预防的补充和替代医学（CAM）是炎症状态下过量NO的抑制剂。在此，我们综述了近期文献，概述了NO/RNS在慢性炎症和癌症中的作用，并指出NO是CAM成功治疗慢性炎症及与此炎症相关癌症的几个靶点之一。
