Clerici M, Pastorino U, Labianca R, Vergani C, Pancera G, De Benedictis R
Minerva Med. 1987 Mar 31;78(6):377-86.
The role of vitamins A, E, C, D, folates and selenium in the chemical prevention of tumours and/or precancerous conditions is examined in the light of epidemiological studies and experimental observations. Particular mention is made of significant clinical studies that provide valuable indications about the use of vitamin A and its derivates in particular for the treatment of precancerous and cancerous conditions. Vitamin A and its derivates apparently play a fundamental role not only in the treatment of proliferating malignancies of the skin (carcinomas, severe aclinic keratosis) or involving the skin (fungoid mycosis, skin metastases of solid tumours) but also in the prevention of recurring bladder tumours and the treatment of several bronchial dysplasias.
根据流行病学研究和实验观察，对维生素A、E、C、D、叶酸和硒在肿瘤和/或癌前病变的化学预防中的作用进行了研究。特别提到了一些重要的临床研究，这些研究为维生素A及其衍生物的使用提供了有价值的指征，特别是在治疗癌前病变和癌症方面。维生素A及其衍生物显然不仅在治疗皮肤增殖性恶性肿瘤（癌、重度光化性角化病）或累及皮肤的疾病（蕈样霉菌病、实体瘤的皮肤转移）中发挥着重要作用，而且在预防复发性膀胱肿瘤和治疗几种支气管发育异常中也发挥着重要作用。
