Resentini M, Cacopardo L, Grugni G, Morabito F
Minerva Med. 1987 Mar 31;78(6):387-91.
Modifications in thyroid function caused by changes in diet have been reported in the literature though the results are often conflicting. The present study was conducted on 48 obese adults divided into two groups: the first over 60% and the second under 60% above their ideal weight. A control group of healthy subjects of normal weight and comparable age was also studied. The observation lasted 9 weeks during which a low calorie diet providing about 1250 kCal was administered. Mean basal levels of FT3, TT3, FT4 and TSH revealed no significant differences between the obese subjects and the control group. Mean TT4 was significantly higher in the obese and mean T3U significantly lower. During low calorie diet treatment the obese subjects produced no significant variations in the above parameters, apart from a significant increase in T3U. The study revealed no evidence of the low T3 syndrome that has long been reported in the literature.
文献中已报道饮食变化会引起甲状腺功能改变，不过结果往往相互矛盾。本研究对48名肥胖成年人进行，分为两组：第一组超过理想体重60%以上，第二组低于理想体重60%以上。还研究了一组体重正常、年龄相仿的健康受试者作为对照组。观察持续9周，在此期间给予提供约1250千卡热量的低热量饮食。FT3、TT3、FT4和TSH的平均基础水平在肥胖受试者和对照组之间无显著差异。肥胖者的平均TT4显著更高，平均T3U显著更低。在低热量饮食治疗期间，肥胖受试者上述参数无显著变化，T3U除外，其显著升高。该研究未发现长期以来文献中报道的低T3综合征的证据。
