Slivka A, Spina M B, Cohen G
Neurosci Lett. 1987 Feb 10;74(1):112-8. doi: 10.1016/0304-3940(87)90061-9.
Prior animal studies have indicated that levels of oxidized glutathione (GSSG) in brain and other organs are low, comprising several percent, or less, of the total glutathione. An exception is seen in reports for autopsy and biopsy specimens of human brain, where very high levels of GSSG have been indicated. The latter observations imply an unusual redox state for human brain. In the current study, GSSG and reduced glutathione (GSH) were measured in monkey brain and autopsy specimens of human brain. Levels of GSSG were 1.2% or less, of the total glutathione. These results are similar to those for rodent brain, but disagree with earlier reports concerning human brain.
先前的动物研究表明，大脑和其他器官中氧化型谷胱甘肽（GSSG）的水平很低，占总谷胱甘肽的百分之几或更少。在关于人类大脑尸检和活检标本的报告中发现了一个例外情况，其中显示GSSG水平非常高。后一种观察结果意味着人类大脑处于一种异常的氧化还原状态。在当前的研究中，对猴脑和人类大脑的尸检标本中的GSSG和还原型谷胱甘肽（GSH）进行了测量。GSSG水平占总谷胱甘肽的1.2%或更低。这些结果与啮齿动物大脑的结果相似，但与早期关于人类大脑的报告不一致。
