Mandal Pravat K, Goel Anshika, Bush Ashley I, Punjabi Khushboo, Joon Shallu, Mishra Ritwick, Tripathi Manjari, Garg Arun, Kumar Natasha K, Sharma Pooja, Shukla Deepika, Ayton Scott Jonathan, Fazlollahi Amir, Maroon Joseph C, Dwivedi Divya, Samkaria Avantika, Sandal Kanika, Megha Kanu, Shandilya Sandhya
National Brain Research Center, NeuroImaging and NeuroSpectroscopy Laboratory (NINS), Gurgaon, India.
Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Brain Commun. 2022 Aug 20;4(5):fcac215. doi: 10.1093/braincomms/fcac215. eCollection 2022.
Oxidative stress has been implicated in Alzheimer's disease, and it is potentially driven by the depletion of primary antioxidant, glutathione, as well as elevation of the pro-oxidant, iron. Present study evaluates glutathione level by magnetic resonance spectroscopy, iron deposition by quantitative susceptibility mapping in left hippocampus, as well as the neuropsychological scores of healthy old participants ( = 25), mild cognitive impairment ( = 16) and Alzheimer's disease patients ( = 31). Glutathione was found to be significantly depleted in mild cognitive impaired ( < 0.05) and Alzheimer's disease patients ( < 0.001) as compared with healthy old participants. A significant higher level of iron was observed in left hippocampus region for Alzheimer's disease patients as compared with healthy old ( < 0.05) and mild cognitive impairment ( < 0.05). Multivariate receiver-operating curve analysis for combined glutathione and iron in left hippocampus region provided diagnostic accuracy of 82.1%, with 81.8% sensitivity and 82.4% specificity for diagnosing Alzheimer's disease patients from healthy old participants. We conclude that tandem glutathione and iron provides novel avenue to investigate further research in Alzheimer's disease.
氧化应激与阿尔茨海默病有关，它可能由主要抗氧化剂谷胱甘肽的消耗以及促氧化剂铁的升高所驱动。本研究通过磁共振波谱评估谷胱甘肽水平，通过定量磁化率成像评估左侧海马体中的铁沉积，以及对健康老年参与者（n = 25）、轻度认知障碍者（n = 16）和阿尔茨海默病患者（n = 31）进行神经心理学评分。与健康老年参与者相比，发现轻度认知障碍者（p < 0.05）和阿尔茨海默病患者（p < 0.001）的谷胱甘肽显著减少。与健康老年人（p < 0.05）和轻度认知障碍者（p < 0.05）相比，阿尔茨海默病患者左侧海马体区域的铁水平显著更高。对左侧海马体区域的谷胱甘肽和铁进行多变量受试者工作特征曲线分析，诊断阿尔茨海默病患者与健康老年参与者的准确率为82.1%，灵敏度为81.8%，特异性为82.4%。我们得出结论，谷胱甘肽和铁联用为阿尔茨海默病的进一步研究提供了新途径。
