Brailowsky S, Menini C, Silva-Barrat C, Naquet R
Neurosci Lett. 1987 Feb 10;74(1):75-80. doi: 10.1016/0304-3940(87)90054-1.
We studied the effects of chronic (7 days) infusion of GABA (100 micrograms/microliter) applied intracortically into the fronto-rolandic (FR) area of baboons, via osmotic minipumps. In photosensitive animals, bilateral GABA application produced a complete blockade of the paroxysmal discharges and associated clinical signs induced by intermittent light stimulation. Unilateral administration had similar effects, although these developed more gradually. At the end of the infusion period, both photosensitive and non-photosensitive animals showed a transitory state (3-4 days) of cortical hyperexcitability (spontaneous epileptogenic activity) localized to the infused area. The data indicate a role of GABA both in the natural photosensitivity of the epileptic baboon and in the withdrawal syndrome consecutive to the sudden interruption of chronically enhanced GABA levels in the FR territories of this monkey.
我们通过渗透微型泵，研究了向狒狒额前运动区（FR）皮层内慢性（7天）输注γ-氨基丁酸（GABA，100微克/微升）的效果。在光敏动物中，双侧应用GABA可完全阻断由间歇性光刺激诱发的阵发放电及相关临床症状。单侧给药也有类似效果，不过起效更为缓慢。在输注期结束时，光敏和非光敏动物均表现出一种短暂状态（3 - 4天），即皮层兴奋性过高（自发性致痫活动），局限于输注区域。数据表明，GABA在癫痫狒狒的自然光敏性以及在该猴FR区域内慢性升高的GABA水平突然中断后的戒断综合征中均发挥作用。
