Brailowski S
Departamento de Neurociencias, Instituto de Fisiología Celular, UNAM.
Gac Med Mex. 1994 Jul-Aug;130(4):259-64.
In this work, we will describe the anatomical, behavioral, electrophysiological and neuropharmacological characteristics of a new model of focal epileptogenesis, the GABA-withdrawal syndrome (GWS). This particular model is original both because the manner in which is induced its electroclinical features, and because the physiopathological implications it represents. We will briefly describe the anticonvulsant effects of chronic, intracortical GABA infusions both in photosensitive baboons and in amygdala kindled rats, and show how the interruption of these infusions lead to the appearance of paroxysmal activity localized at the infusion sites. We will then describe more in detail this GWS, and show its dependency on GABA A receptor function. Furthermore, this GWS can be induced in hippocampal slices. Finally, we will propose the GWS as a useful model to study plastic phenomena in the brain and as a model of intractable epilepsy where screening of potential anticonvulsant agents will be feasible.
在这项工作中，我们将描述一种新的局灶性癫痫发生模型——γ-氨基丁酸（GABA）撤药综合征（GWS）的解剖学、行为学、电生理学和神经药理学特征。这个特殊的模型具有独特之处，既在于其诱发电临床特征的方式，也在于其所代表的病理生理学意义。我们将简要描述慢性皮质内注射GABA对光敏狒狒和杏仁核点燃大鼠的抗惊厥作用，并展示这些注射的中断如何导致在注射部位出现阵发性活动。然后，我们将更详细地描述这种GWS，并展示其对GABAA受体功能的依赖性。此外，这种GWS可在海马切片中诱发。最后，我们将提出GWS作为研究大脑可塑性现象的有用模型，以及作为难治性癫痫的模型，在此模型中筛选潜在的抗惊厥药物将是可行的。
