Ferri G L, Morreale R A, Soimero L, Biliotti G, Dockray G J
Neurosci Lett. 1987 Mar 9;74(3):304-8. doi: 10.1016/0304-3940(87)90314-4.
The intramural distribution of Met5-enkephalin-Arg6-Gly7-Leu8 (MERGL) was studied in the oesophago-cardiac, pyloric, ileo-caecal and sigmoid-recto-anal regions of the human digestive tract. Serial samples encompassing each area were separated into mucosa, submucosa and muscularis externa and extracted for radioimmunoassay. Comparatively low levels of MERGL immunoreactivity were measured throughout the cardiac junction. Conversely, a remarkable peak of MERGL concentration was detected at the pyloric junction, in both submucosa and muscularis. A progressive decrease in tissue levels of the same peptide, most evident in the submucosa, was detected on the proximal side of the ileo-caecal region. In the distal sigmoid colon and rectum MERGL concentrations showed a rapid decline, down to very low levels in the anal canal. The results may suggest the involvement of an enkephalinergic mechanism in the control of the human pylorus.
研究了甲硫氨酸脑啡肽-精氨酸6-甘氨酸7-亮氨酸8（MERGL）在人消化道食管-贲门、幽门、回盲部和乙状结肠-直肠-肛管区域的壁内分布。包含每个区域的系列样本被分离为黏膜、黏膜下层和肌层，并提取用于放射免疫分析。在整个贲门交界处测得的MERGL免疫反应性水平相对较低。相反，在幽门交界处的黏膜下层和肌层均检测到MERGL浓度显著峰值。在回盲部区域近端，同一肽的组织水平逐渐下降，在黏膜下层最为明显。在乙状结肠远端和直肠，MERGL浓度迅速下降，在肛管降至非常低的水平。结果可能提示脑啡肽能机制参与了对人幽门的控制。
