Spano Luana, Hennion Vincent, Marie-Claire Cynthia, Bellivier Frank, Scott Jan, Etain Bruno
INSERM UMR-S 1144, Optimisation Thérapeutique en Neurospsychopharmacologie, OTeN, Université de Paris, 75006, Paris, France.
Université de Paris, Paris, France.
Int J Bipolar Disord. 2022 May 27;10(1):14. doi: 10.1186/s40345-022-00260-w.
Life expectancy is significantly decreased in bipolar disorder (BD). This is associated with accelerated cellular aging which can be estimated by telomere length (TL). However, specific determinants of shorter TL in BD are under-explored. This study examines whether circadian misalignment (i.e. mismatch between preferred and actual phase of circadian activity rhythms) is associated with shorter TL in BD.
Euthymic individuals with BD (n = 101) undertook 21 consecutive days of actigraphy recording and completed the Composite Scale of Morningness (CSM) to assess phase preference for activities (chronotype). Polymerase chain reaction was used to measure TL in blood. Cluster analysis identified circadian aligned/misaligned subgroups as defined by preferred (CSM score) and actual phases of activity (actigraphically determined onset of active and inactive periods). We tested for any associations between TL and clusters, with adjustments for between-cluster differences in socio-demographic and illness factors.
We identified three clusters: an "Aligned Morning" cluster (n = 31) with preferred and actual timing of activity in the morning, an "Aligned Evening" cluster (n = 37) with preferred and actual timing of activity in the evening and a "Misaligned" cluster (n = 32) with an evening chronotype, but an earlier objective onset of active periods. After adjustment for confounders, we found that TL was significantly associated with circadian misalignment and older age.
Circadian misalignment may partly explain shorter TL in BD and could contribute to accelerated aging in these individuals.
双相情感障碍（BD）患者的预期寿命显著缩短。这与细胞衰老加速有关，而细胞衰老可通过端粒长度（TL）来估计。然而，BD患者端粒长度较短的具体决定因素尚未得到充分研究。本研究探讨昼夜节律失调（即昼夜活动节律的偏好相位与实际相位不匹配）是否与BD患者较短的端粒长度相关。
101名处于心境正常期的BD患者连续进行21天的活动记录仪记录，并完成晨型综合量表（CSM）以评估活动的相位偏好（昼夜节律类型）。采用聚合酶链反应测量血液中的端粒长度。聚类分析根据偏好相位（CSM评分）和活动实际相位（通过活动记录仪确定的活跃期和非活跃期开始时间）确定昼夜节律对齐/失调亚组。我们测试了端粒长度与聚类之间的任何关联，并对社会人口统计学和疾病因素在聚类间的差异进行了调整。
我们识别出三个聚类：一个“早晨对齐”聚类（n = 31），其活动的偏好时间和实际时间均在早晨；一个“晚上对齐”聚类（n = 37），其活动的偏好时间和实际时间均在晚上；以及一个“失调”聚类（n = 32），其昼夜节律类型为晚上型，但活跃期的客观开始时间较早。在对混杂因素进行调整后，我们发现端粒长度与昼夜节律失调和年龄较大显著相关。
昼夜节律失调可能部分解释了BD患者端粒长度较短的原因，并可能导致这些个体加速衰老。
