National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Commun Biol. 2023 Oct 6;6(1):1014. doi: 10.1038/s42003-023-05397-7.
Observational studies suggest certain sleep traits are associated with telomere length, but the causal nature of these associations is unclear. The study aimed to determine the causal associations between 11 sleep-related traits and leukocyte telomere length (LTL) through two-sample Mendelian randomization and colocalization analyses using the summary statistics from large-scale genome-wide association studies. Univariable Mendelian randomization indicates that genetically determined short sleep is associated with decreased LTL, while morning chronotype is associated with increased LTL. Multivariable Mendelian randomization further supports the findings and colocalization analysis identifies shared common genetic variants for these two associations. No genetic evidence is observed for associations between other sleep-related traits and LTL. Sensitivity MR methods, reverse MR and re-running MR after removing potential pleiotropic genetic variants enhance the robustness of the results. These findings indicate that prioritizing morning chronotype and avoiding short sleep is beneficial for attenuating telomere attrition. Consequently, addressing sleep duration and chronotype could serve as practical intervention strategies.
观察性研究表明，某些睡眠特征与端粒长度有关，但这些关联的因果性质尚不清楚。本研究旨在通过使用来自大规模全基因组关联研究的汇总统计数据，通过两样本 Mendelian 随机化和共定位分析，确定 11 种与睡眠相关的特征与白细胞端粒长度（LTL）之间的因果关联。单变量 Mendelian 随机化表明，遗传决定的短睡眠与 LTL 降低有关，而早晨型与 LTL 增加有关。多变量 Mendelian 随机化进一步支持了这些发现，并且共定位分析确定了这两个关联的共享常见遗传变异。没有观察到其他与睡眠相关的特征与 LTL 之间存在关联的遗传证据。敏感性 MR 方法、反向 MR 和在去除潜在的多效性遗传变异后重新运行 MR 增强了结果的稳健性。这些发现表明，优先选择早晨型和避免短睡眠有利于减缓端粒损耗。因此，解决睡眠持续时间和昼夜节律问题可能是一种实用的干预策略。
