Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Endocrinol Metab (Seoul). 2022 Jun;37(3):487-496. doi: 10.3803/EnM.2022.1428. Epub 2022 May 27.
Although muscles and bones interact with each other through various secretory factors, the role of sclerostin, an osteocyte-secreted factor, on muscle metabolism has not been well studied. We investigated the levels of serum sclerostin in Korean older adults with sarcopenia.
Blood samples were collected from 129 participants who underwent evaluation of muscle mass and function in an outpatient geriatric clinic of a teaching hospital. Sarcopenia and related parameters were determined using cutoff values for the Asian population. Serum sclerostin levels were measured using an enzyme-linked immunosorbent assay.
The mean age of the participants was 69.6 years, and 20 participants (15.5%) were classified as having sarcopenia. After adjusting for age, sex, and body mass index, serum sclerostin levels were significantly lower in participants with sarcopenia, low muscle mass, or weak muscle strength (P=0.003 to 0.045). Serum sclerostin levels were positively associated with skeletal muscle index and grip strength after adjusting for confounders (P=0.001 and P=0.003), whereas sarcopenic phenotype score showed a negative association (P=0.006). These increases in muscle mass and strength were also dose dependent as serum sclerostin levels increased (P for trends=0.003 and P for trends=0.015). Higher serum sclerostin levels were associated with lower odds ratio (ORs) for sarcopenia, low muscle mass, and weak muscle strength after adjusting for confounders (OR, 0.27 to 0.50; P<0.001 to 0.025).
Higher serum sclerostin levels were associated with a lower risk of sarcopenia, low muscle mass, and weak muscle strength in Korean older adults.
尽管肌肉和骨骼通过各种分泌因子相互作用，但骨钙素蛋白（一种骨细胞分泌的因子）对肌肉代谢的作用尚未得到充分研究。我们研究了血清骨钙素蛋白水平在韩国老年人群中与肌肉减少症的关系。
从在教学医院的老年门诊接受肌肉质量和功能评估的 129 名参与者中采集血样。使用亚洲人群的截断值确定肌肉减少症和相关参数。使用酶联免疫吸附试验测量血清骨钙素蛋白水平。
参与者的平均年龄为 69.6 岁，20 名参与者（15.5%）被归类为患有肌肉减少症。在校正年龄、性别和体重指数后，患有肌肉减少症、低肌肉质量或肌肉力量弱的参与者的血清骨钙素蛋白水平显著较低（P=0.003 至 0.045）。在校正混杂因素后，血清骨钙素蛋白水平与骨骼肌指数和握力呈正相关（P=0.001 和 P=0.003），而肌肉减少症表型评分呈负相关（P=0.006）。随着血清骨钙素蛋白水平的升高，肌肉质量和力量的增加也是剂量依赖性的（P 趋势=0.003 和 P 趋势=0.015）。在校正混杂因素后，较高的血清骨钙素蛋白水平与较低的肌肉减少症、低肌肉质量和肌肉力量弱的比值比（OR）相关（OR，0.27 至 0.50；P<0.001 至 0.025）。
在韩国老年人群中，较高的血清骨钙素蛋白水平与较低的肌肉减少症、低肌肉质量和肌肉力量弱的风险相关。
