Department of Chemistry, The University of the West Indies, St. Augustine, Trinidad and Tobago, Kingston, Jamaica.
Curr Diabetes Rev. 2023;19(4):e190522205040. doi: 10.2174/1573399818666220519163350.
Diabetes is a chronic metabolic disorder with a high global prevalence and one of the highest morbidity and mortality rates. Despite developments in synthetic medicine, the associated serious side effects with current antidiabetic drugs indicate an urgent need for novel effective treatments. Traditional medicinal plants offer great potential in the treatment of many diseases due to their bioactive phytochemicals and are a useful resource for developing safe and effective hypoglycemic agents.
The present review collates the most frequently used ethnomedicines for the management of diabetes mellitus in Trinidad and Tobago. Further, it provides scientific validation of the claimed antidiabetic effects of four selected ethnomedicines: Antigonon leptopus, Gomphrena globosa, Laportea aestuans and Stachytarpheta jamaicensis. A comprehensive literature search was conducted using various electronic scientific databases and search engines. Information was collected on the phytochemical and pharmacological aspects of these selected species to illustrate the antidiabetic activity and potential applications of these plants.
The findings of the numerous in vitro and in vivo experiments from previously published literature indicate the four candidate plants as promising sources of antidiabetic lead compounds and provide useful information to stimulate extensive studies. Further investigations on the isolation, identification and clinical evaluation of the pharmacologically active constituents from these plants can lead to the discovery of new and effective antidiabetic agents.
糖尿病是一种慢性代谢紊乱疾病，具有较高的全球患病率，以及最高的发病率和死亡率之一。尽管合成药物有所发展，但目前抗糖尿病药物的相关严重副作用表明，急需新型有效治疗方法。由于药用植物的生物活性植物化学物质，它们在治疗许多疾病方面具有巨大的潜力，是开发安全有效的降血糖药物的有用资源。
本综述汇集了特立尼达和多巴哥用于治疗糖尿病的最常用民族医学。此外，它还为四种选定的民族药物的抗糖尿病作用提供了科学验证：Leptopus Antigonon、Gomphrena globosa、Laportea aestuans 和 Stachytarpheta jamaicensis。使用各种电子科学数据库和搜索引擎进行了全面的文献检索。收集了这些选定物种的植物化学和药理学方面的信息，以说明这些植物的抗糖尿病活性和潜在应用。
先前发表的文献中的大量体外和体内实验结果表明，这四种候选植物是有前途的抗糖尿病先导化合物来源，并提供了有用的信息来刺激广泛的研究。对这些植物中具有药理活性的成分进行分离、鉴定和临床评估的进一步研究可能会发现新的有效抗糖尿病药物。
