Department of Pharmacy, Independent University, Dhaka 1229, Bangladesh.
School of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, UK.
Molecules. 2022 Jul 3;27(13):4278. doi: 10.3390/molecules27134278.
Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority of people living in underdeveloped countries. Medicinal plants have been used traditionally throughout the ages to treat various ailments due to their availability and safe nature. Medicinal plants are a rich source of phytochemicals that possess several health benefits. As diabetes continues to become prevalent, health care practitioners are considering plant-based medicines as a potential source of antidiabetic drugs due to their high potency and fewer side effects. To better understand the mechanism of action of medicinal plants, their active phytoconstituents are being isolated and investigated thoroughly. In this review article, we have focused on pharmacologically active phytomolecules isolated from medicinal plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes. These natural compounds may represent as good candidates for a novel therapeutic approach and/or effective and alternative therapies for diabetes.
糖尿病是一种影响各年龄段人群的慢性并发症。全球糖尿病患病率的上升导致了几种合成药物的开发，以解决这一健康问题。这些药物虽然作为抗高血糖药物有效，但伴随着各种副作用、昂贵且大多数生活在欠发达国家的人无法获得。药用植物因其可用性和安全性而在过去的几个世纪中一直被用于治疗各种疾病。药用植物是具有多种健康益处的植物化学物质的丰富来源。随着糖尿病的持续流行，医疗保健从业者正在考虑植物药作为抗糖尿病药物的潜在来源，因为它们具有高效力和较少的副作用。为了更好地了解药用植物的作用机制，正在对其具有生物活性的植物成分进行分离和深入研究。在这篇综述文章中，我们重点介绍了具有抗糖尿病活性的药用植物中分离出的具有药理学活性的植物分子，以及它们在糖尿病治疗和管理中的作用。这些天然化合物可能是一种新的治疗方法和/或有效和替代糖尿病治疗的良好候选物。
