Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio-agriculture, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Wetlands, Yancheng Teachers University, Yancheng, China.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Front Immunol. 2022 May 10;13:874605. doi: 10.3389/fimmu.2022.874605. eCollection 2022.
Emerging evidence reveals that the stimulator of the interferon genes (STING) signaling pathway in insects and other animal cells helps them to sense and effectively respond to infection caused by numerous types of microbial pathogens. Recent studies have shown that genomic material from microbial pathogens induces the STING signaling pathway for the production of immune factors to attenuate infection. In contrast, microbial pathogens are equipped with various factors that assist them in evading the STING signaling cascade. Here we discuss the STING signaling pathway different animal groups compared to human and then focus on its crucial biological roles and application in the microbial infection of insects. In addition, we examine the negative and positive modulators of the STING signaling cascade. Finally, we describe the microbial pathogen strategies to evade this signaling cascade for successful invasion.
新兴证据表明，昆虫和其他动物细胞中的干扰素基因刺激物 (STING) 信号通路有助于它们感知和有效应对多种类型的微生物病原体引起的感染。最近的研究表明，微生物病原体的基因组物质诱导 STING 信号通路产生免疫因子以减轻感染。相比之下，微生物病原体配备了各种有助于它们逃避 STING 信号级联的因子。在这里，我们将讨论 STING 信号通路在不同动物群体与人类之间的差异，然后重点介绍其在昆虫微生物感染中的关键生物学作用和应用。此外，我们还研究了 STING 信号级联的负调节剂和正调节剂。最后，我们描述了微生物病原体逃避这种信号级联以成功入侵的策略。
