血清白细胞介素-17、血管内皮生长因子及乳酸脱氢酶水平与胃癌预后的相关性

Correlation of Serum IL-17, VEGF, and Lactate Dehydrogenase (LDH) Levels with Prognosis of Gastric Cancer.

作者信息

Rao Shumei, Zhao Lifang, Zheng Xia, Li Shiwei, Tian Xifeng

机构信息

Medical School, Tianshi College, Tianjin, China.

Luohe Medicine College, Luohe, China.

出版信息

Evid Based Complement Alternat Med. 2022 May 17;2022:8126672. doi: 10.1155/2022/8126672. eCollection 2022.

DOI:10.1155/2022/8126672

PMID:35620403

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9129953/

Abstract

OBJECTIVE

To investigate the correlation of serum interleukin-17 (IL-17), vascular endothelial growth factor (VEGF) and lactate dehydrogenase (LDH) levels with the prognosis of gastric cancer patients.

METHODS

From December 2018 to December 2020, 45 patients with gastric cancer treated in our hospital and 50 healthy individuals were assessed for eligibility and recruited. The eligible patients were assigned to an observation group, and the healthy subjects were assigned to a control group. Serum IL-17, LDH, and VEGF levels of the eligible participants were determined by the enzyme-linked immunosorbent assay (ELISA) and biochemical testing. The association of serum IL-7, LDH, and VEGF levels with their pathological characteristics was examined in the observation group. The correlation between serum IL-17 and VEGF was analyzed using the Pearson method, and regression models were established using COX proportional risk to explore the independent risk factors for gastric cancer.

RESULTS

Gastric cancer was associated with higher levels of IL-17, LDH, and VEGF versus a healthy status ( < 0.05). There was no significant difference in serum IL-17, LDH, and VEGF levels between the two groups of patients with different clinical characteristics ( > 0.05). Higher tumor TNM stages resulted in significantly higher levels of IL-17, LDH, and VEGF ( < 0.05). Serum IL-17 level was positively correlated with VEGF level ( < 0.05). Cox regression multifactorial analysis showed that serum IL-17, LDH, VEGF, and tumor TNM stages could be independent high-risk influencing factors for gastric cancer ( < 0.05). Serum IL-17 was positively correlated with VEGF levels in patients with gastric cancer.

CONCLUSION

Serum IL-17, LDH, and VEGF levels in gastric cancer patients are closely correlated with the TNM stage and patients' prognosis, both of which show great potential as effective indicators for evaluating the prognosis of gastric cancer.

摘要

目的

探讨血清白细胞介素-17（IL-17）、血管内皮生长因子（VEGF）和乳酸脱氢酶（LDH）水平与胃癌患者预后的相关性。

方法

2018年12月至2020年12月，对我院收治的45例胃癌患者和50例健康个体进行资格评估并招募。符合条件的患者被分配到观察组，健康受试者被分配到对照组。采用酶联免疫吸附测定（ELISA）和生化检测方法测定符合条件参与者的血清IL-17、LDH和VEGF水平。在观察组中检查血清IL-7、LDH和VEGF水平与其病理特征的相关性。采用Pearson法分析血清IL-17与VEGF的相关性，并采用COX比例风险建立回归模型，探讨胃癌的独立危险因素。

结果

与健康状态相比，胃癌患者的IL-17、LDH和VEGF水平较高（<0.05）。两组不同临床特征患者的血清IL-17、LDH和VEGF水平无显著差异（>0.05）。肿瘤TNM分期越高，IL-17、LDH和VEGF水平越高（<0.05）。血清IL-17水平与VEGF水平呈正相关（<0.05）。Cox回归多因素分析显示，血清IL-17、LDH、VEGF和肿瘤TNM分期可能是胃癌的独立高危影响因素（<0.05）。胃癌患者血清IL-17与VEGF水平呈正相关。